DCK

DCK
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauDCK, entrez:1633, deoxycytidine kinase
Dynodwyr allanolOMIM: 125450 HomoloGene: 616 GeneCards: DCK
EC number2.7.1.74+ 2.7.1.76 2.7.1.113, 2.7.1.74, 2.7.1.76
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

1633

n/a

Ensembl

ENSG00000156136

n/a

UniProt

P27707

n/a

RefSeq (mRNA)

NM_000788

n/a

RefSeq (protein)

NP_000779

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DCK yw DCK a elwir hefyd yn Deoxycytidine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q13.3.[2]

Llyfryddiaeth

  • "dCK Expression and Gene Polymorphism With Gemcitabine Chemosensitivity in Patients With Pancreatic Ductal Adenocarcinoma: A Strobe-Compliant Observational Study. ". Medicine (Baltimore). 2016. PMID 26962792.
  • "Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase. ". PLoS One. 2015. PMID 26485161.
  • "Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK. ". Biochem Biophys Res Commun. 2015. PMID 26196746.
  • "Impact of single nucleotide polymorphisms of cytarabine metabolic genes on drug toxicity in childhood acute lymphoblastic leukemia. ". Pediatr Blood Cancer. 2015. PMID 25557962.
  • "Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis.". Am J Respir Crit Care Med. 2014. PMID 25358054.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ DCK - Cronfa NCBI

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