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EXOSC10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CPR, 3SAF, 3SAG, 3SAH
Dynodwyr
Cyfenwau	EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4, exosome component 10
Dynodwyr allanol	OMIM: 605960 HomoloGene: 31105 GeneCards: EXOSC10
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • exoribonuclease activity; • GO:0001948, GO:0016582 protein binding; • catalytic activity; • 3'-5' exonuclease activity; • nucleic acid binding; • nuclease activity; • exonuclease activity; • hydrolase activity; • RNA binding; • 3'-5'-exoribonuclease activity; • telomerase RNA binding; • single-stranded RNA binding;
Cydrannau o'r gell	• cytoplasm; • exosome (RNase complex); • bilen; • nuclear exosome (RNase complex); • intracellular anatomical structure; • nucleolus; • cnewyllyn cell; • nucleoplasm; • cytosol;
Prosesau biolegol	• GO:0033168, GO:0036404, GO:1902360 RNA processing; • nuclear polyadenylation-dependent rRNA catabolic process; • nucleic acid phosphodiester bond hydrolysis; • CUT catabolic process; • nuclear-transcribed mRNA catabolic process; • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance; • metaboledd celloedd; • maturation of 5.8S rRNA; • histone mRNA catabolic process; • dosage compensation by inactivation of X chromosome; • nucleobase-containing compound metabolic process; • rRNA processing; • RNA phosphodiester bond hydrolysis, exonucleolytic; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • negative regulation of telomere maintenance via telomerase; • regulation of telomerase RNA localization to Cajal body; • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); • nuclear polyadenylation-dependent snoRNA catabolic process; • nuclear polyadenylation-dependent snRNA catabolic process; • nuclear polyadenylation-dependent tRNA catabolic process; • nuclear polyadenylation-dependent CUT catabolic process; • nuclear polyadenylation-dependent antisense transcript catabolic process; • polyadenylation-dependent snoRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologau
	5394
	n/a
	ENSG00000171824
	n/a
	Q01780
	n/a
	NM_001001998; NM_002685
	n/a
	NP_001001998; NP_002676
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC10 yw EXOSC10 a elwir hefyd yn Exosome component 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC10.

p2
p3
p4
RRP6
PMSCL
Rrp6p
PM-Scl
PMSCL2
PM/Scl-100

Llyfryddiaeth

"Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. ". Arthritis Res Ther. 2009. PMID 19220911.
"PM1-Alpha ELISA: the assay of choice for the detection of anti-PM/Scl autoantibodies?". Autoimmun Rev. 2009. PMID 19103309.
"Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis. ". RNA. 2016. PMID 26857222.
"Anti-PM-Scl antibody in patients with systemic sclerosis. ". Clin Exp Rheumatol. 2012. PMID 22261302.
"Activities of human RRP6 and structure of the human RRP6 catalytic domain.". RNA. 2011. PMID 21705430.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EXOSC10 - Cronfa NCBI

[1]

[2]

EXOSC10

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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