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KCNH2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G
Dynodwyr
Cyfenwau	KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2
Dynodwyr allanol	OMIM: 152427 HomoloGene: 201 GeneCards: KCNH2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• potassium channel activity; • protein homodimerization activity; • scaffold protein binding; • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; • C3HC4-type RING finger domain binding; • voltage-gated ion channel activity; • ion channel activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; • voltage-gated potassium channel activity; • phosphorelay sensor kinase activity; • ubiquitin protein ligase binding; • delayed rectifier potassium channel activity; • inward rectifier potassium channel activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • voltage-gated potassium channel complex; • cellbilen; • cell surface; • perinuclear region of cytoplasm; • inward rectifier potassium channel complex; • integral component of plasma membrane;
Prosesau biolegol	• membrane depolarization during action potential; • cardiac muscle contraction; • GO:0072468 signal transduction; • regulation of membrane potential; • regulation of ion transmembrane transport; • ventricular cardiac muscle cell action potential; • cludo ïon; • potassium ion export across plasma membrane; • potassium ion transport; • membrane repolarization during action potential; • potassium ion homeostasis; • regulation of heart rate by hormone; • transmembrane transport; • potassium ion transmembrane transport; • positive regulation of potassium ion transmembrane transport; • phosphorelay signal transduction system; • regulation of membrane repolarization; • negative regulation of potassium ion transmembrane transport; • membrane repolarization during cardiac muscle cell action potential; • regulation of heart rate by cardiac conduction; • regulation of potassium ion transmembrane transport; • regulation of ventricular cardiac muscle cell membrane repolarization; • membrane repolarization during ventricular cardiac muscle cell action potential; • membrane repolarization; • negative regulation of potassium ion export across plasma membrane; • potassium ion import across plasma membrane; • cardiac conduction;
	Sources:Amigo / QuickGO
Orthologau
	3757
	n/a
	ENSG00000055118
	n/a
	Q12809
	n/a
	NM_000238; NM_001204798; NM_172056; NM_172057
	n/a
	NP_000229; NP_001191727; NP_742053; NP_742054
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCNH2 yw KCNH2 a elwir hefyd yn Potassium voltage-gated channel subfamily H member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q36.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCNH2.

ERG1
HERG
LQT2
SQT1
ERG-1
H-ERG
HERG1
Kv11.1

Llyfryddiaeth

"The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues. ". Biophys J. 2017. PMID 29117522.
"Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA. ". Gene. 2018. PMID 29066300.
"Hypoxia reduces mature hERG channels through calpain up-regulation. ". FASEB J. 2017. PMID 28784631.
"Cryo-EM Structure of the Open Human Ether-Ã -go-go-Related K+ Channel hERG. ". Cell. 2017. PMID 28431243.
"Comparative study of the structure and interaction of the pore helices of the hERG and Kv1.5 potassium channels in model membranes.". Eur Biophys J. 2017. PMID 28314880.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KCNH2 - Cronfa NCBI

[1]

[2]

KCNH2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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