MANF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KVD, 2KVE, 2W51
Dynodwyr
Cyfenwau	MANF, ARMET, ARP, arginine-rich, mutated in early-stage tumors, arginine-rich protein, mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte derived neurotrophic factor
Dynodwyr allanol	OMIM: 601916 HomoloGene: 4383 GeneCards: MANF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • growth factor activity • RNA binding • lipid binding • sulfatide binding Cydrannau o'r gell • cnewyllyn cell • extracellular region • extracellular space • Reticwlwm endoplasmig • cytosol • endoplasmic reticulum lumen • sarcoplasmic reticulum • sarcoplasmic reticulum lumen Prosesau biolegol • response to unfolded protein • platelet degranulation • neuron projection development • dopaminergic neuron differentiation • regulation of signaling receptor activity • regulation of response to endoplasmic reticulum stress • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7873	n/a
Ensembl	ENSG00000145050	n/a
UniProt	P55145	n/a
RefSeq (mRNA)	NM_006010	n/a
RefSeq (protein)	NP_006001	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MANF yw MANF a elwir hefyd yn Mesencephalic astrocyte derived neurotrophic factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p21.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MANF.

• ARP
• ARMET

• "Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury. ". Exp Neurol. 2010. PMID 20685313.
• "Novel CDNF/MANF family of neurotrophic factors. ". Dev Neurobiol. 2010. PMID 20186704.
• "Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance. ". Endocr J. 2017. PMID 28216543.
• "Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity. ". Cell Death Dis. 2015. PMID 26720341.
• "ER stress-inducible protein MANF selectively expresses in human spleen.". Hum Immunol. 2015. PMID 26429332.