POLM

POLM
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauPOLM, Pol Mu, Tdt-N, DNA polymerase mu, polymerase (DNA) mu
Dynodwyr allanolOMIM: 606344 HomoloGene: 41170 GeneCards: POLM
EC number2.7.7.7
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

27434

n/a

Ensembl

ENSG00000122678

n/a

UniProt

Q9NP87

n/a

RefSeq (mRNA)

NM_001284330
NM_001284331
NM_013284
NM_001362683

n/a

RefSeq (protein)

NP_001271259
NP_001271260
NP_037416
NP_001349612

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLM yw POLM a elwir hefyd yn DNA polymerase mu (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p13.[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLM.

  • Tdt-N
  • Pol*Mu

Llyfryddiaeth

  • "Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging. ". Nucleic Acids Res. 2014. PMID 24878922.
  • "Sustained active site rigidity during synthesis by human DNA polymerase μ. ". Nat Struct Mol Biol. 2014. PMID 24487959.
  • "Polμ tumor variants decrease the efficiency and accuracy of NHEJ. ". Nucleic Acids Res. 2017. PMID 28973441.
  • "Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. ". Nucleic Acids Res. 2017. PMID 28911097.
  • "Creative template-dependent synthesis by human polymerase mu.". Proc Natl Acad Sci U S A. 2015. PMID 26240373.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ POLM - Cronfa NCBI

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