PRMT3

PRMT3
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauPRMT3, HRMT1L3, protein arginine methyltransferase 3
Dynodwyr allanolOMIM: 603190 HomoloGene: 24255 GeneCards: PRMT3
EC number2.1.1.319
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

10196

n/a

Ensembl

ENSG00000185238

n/a

UniProt

O60678

n/a

RefSeq (mRNA)

NM_001145166
NM_001145167
NM_005788

n/a

RefSeq (protein)

NP_001138638
NP_001138639
NP_005779

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRMT3 yw PRMT3 a elwir hefyd yn Protein arginine methyltransferase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.1.[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRMT3.

  • HRMT1L3

Llyfryddiaeth

  • "Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. ". Mol Biosyst. 2011. PMID 21866297.
  • "Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3). ". Biochim Biophys Acta. 2011. PMID 21059412.
  • "Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. ". ACS Chem Biol. 2014. PMID 24320160.
  • "Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. ". J Med Chem. 2013. PMID 23445220.
  • "An allosteric inhibitor of protein arginine methyltransferase 3.". Structure. 2012. PMID 22795084.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ PRMT3 - Cronfa NCBI

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