TDP1

TDP1
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauTDP1, tyrosyl-DNA phosphodiesterase 1
Dynodwyr allanolOMIM: 607198 HomoloGene: 5424 GeneCards: TDP1
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

55775

n/a

Ensembl

ENSG00000042088

n/a

UniProt

Q9NUW8

n/a

RefSeq (mRNA)

NM_001008744
NM_018319
NM_001330205

n/a

RefSeq (protein)

NP_001008744
NP_001317134
NP_060789

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TDP1 yw TDP1 a elwir hefyd yn Tyrosyl-DNA phosphodiesterase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.11.[2]

Llyfryddiaeth

  • "TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. ". DNA Repair (Amst). 2015. PMID 25841101.
  • "Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage. ". J Biol Chem. 2015. PMID 25609251.
  • "TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors. ". Mol Cancer Ther. 2017. PMID 28802254.
  • "Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells. ". Mutat Res. 2015. PMID 26421495.
  • "A Theoretical Study of Phosphoryl Transfers of Tyrosyl-DNA Phosphodiesterase I (Tdp1) and the Possibility of a "Dead-End" Phosphohistidine Intermediate.". Biochemistry. 2015. PMID 26121557.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ TDP1 - Cronfa NCBI

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