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TLR2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Dynodwyr
Cyfenwau	TLR2, CD282, TIL4, toll like receptor 2
Dynodwyr allanol	OMIM: 603028 HomoloGene: 20695 GeneCards: TLR2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0008329 pattern recognition receptor activity; • lipopolysaccharide binding; • Toll-like receptor binding; • triacyl lipopeptide binding; • GO:0001948, GO:0016582 protein binding; • peptidoglycan binding; • protein heterodimerization activity; • lipopolysaccharide immune receptor activity; • transmembrane signaling receptor activity; • lipopeptide binding;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • phagocytic vesicle membrane; • Golgi apparatus; • bilen; • intrinsic component of plasma membrane; • cellbilen; • Toll-like receptor 1-Toll-like receptor 2 protein complex; • integral component of plasma membrane; • membrane raft; • GO:0016023 cytoplasmic vesicle; • cell projection; • cell surface; • cell body;
Prosesau biolegol	• interleukin-10 production; • positive regulation of interferon-beta production; • GO:0051637 defense response to Gram-positive bacterium; • positive regulation of interleukin-18 production; • positive regulation of toll-like receptor signaling pathway; • toll-like receptor TLR1:TLR2 signaling pathway; • positive regulation of inflammatory response; • cellular response to bacterial lipopeptide; • positive regulation of interleukin-12 production; • proses y system imiwnedd; • detection of diacyl bacterial lipopeptide; • cellular response to diacyl bacterial lipopeptide; • I-kappaB phosphorylation; • positive regulation of nitric-oxide synthase biosynthetic process; • MyD88-dependent toll-like receptor signaling pathway; • cellular response to triacyl bacterial lipopeptide; • detection of triacyl bacterial lipopeptide; • positive regulation of Wnt signaling pathway; • GO:1901313 positive regulation of gene expression; • cellular response to lipoteichoic acid; • positive regulation of NF-kappaB transcription factor activity; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of interleukin-8 production; • positive regulation of interleukin-6 production; • positive regulation of tumor necrosis factor production; • positive regulation of chemokine production; • innate immune response; • inflammatory response; • toll-like receptor TLR6:TLR2 signaling pathway; • response to molecule of bacterial origin; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0097285 apoptotic process; • response to lipopolysaccharide; • response to progesterone; • toll-like receptor signaling pathway; • response to insulin; • central nervous system myelin formation; • nitric oxide metabolic process; • response to fatty acid; • leukotriene metabolic process; • toll-like receptor 2 signaling pathway; • positive regulation of oligodendrocyte differentiation; • response to bacterial lipoprotein; • negative regulation of cell population proliferation; • response to toxic substance; • response to hypoxia; • positive regulation of interleukin-10 production; • lipopolysaccharide-mediated signaling pathway; • microglial cell activation;
	Sources:Amigo / QuickGO
Orthologau
	7097
	n/a
	ENSG00000137462
	n/a
	O60603
	n/a
NM_003264; NM_001318787; NM_001318789; NM_001318790; NM_001318791;
	NM_001318793; NM_001318795; NM_001318796
	n/a
NP_001305716; NP_001305718; NP_001305719; NP_001305720; NP_001305722;
	NP_001305724; NP_001305725; NP_003255
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR2 yw TLR2 a elwir hefyd yn Toll like receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q31.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR2.

TIL4
CD282

Llyfryddiaeth

"Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2. ". Infect Immun. 2018. PMID 29084899.
"Toll-like receptor 2 and its roles in immune responses against Legionella pneumophila. ". Life Sci. 2017. PMID 28887059.
"Toll-like receptor 2 and type 2 diabetes. ". Cell Mol Biol Lett. 2016. PMID 28536605.
"Association of single-nucleotide polymorphisms in toll-like receptor 2 gene with asthma susceptibility: A meta-analysis. ". Medicine (Baltimore). 2017. PMID 28514297.
"Surface Expression and Genetic Variants of Toll-like Receptor 2 in Pulmonary Tuberculosis Patients.". Egypt J Immunol. 2016. PMID 28502147.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TLR2 - Cronfa NCBI

[1]

[2]

TLR2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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