Class of enzymes
(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.247 , methyltransferase 2 , MT2 , MT2-A , mtbA (gene) ) is an enzyme with systematic name methylated monomethylamine-specific corrinoid protein:coenzyme M methyltransferase .[1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction
[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M ⇌ methyl-CoM + [Co(I) methylamine-specific corrinoid protein]
This enzyme contains zinc .
References
^ Burke SA, Krzycki JA (August 1995). "Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine" . Journal of Bacteriology . 177 (15): 4410–6. PMC 177191 . PMID 7635826 .
^ LeClerc GM, Grahame DA (August 1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression" . The Journal of Biological Chemistry . 271 (31): 18725–31. doi :10.1074/jbc.271.31.18725 . PMID 8702528 .
^ Ferguson DJ, Krzycki JA (February 1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri" . Journal of Bacteriology . 179 (3): 846–52. doi :10.1128/jb.179.3.846-852.1997 . PMC 178769 . PMID 9006042 .
^ Burke SA, Lo SL, Krzycki JA (July 1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine" . Journal of Bacteriology . 180 (13): 3432–40. PMC 107300 . PMID 9642198 .
^ Ferguson DJ, Gorlatova N, Grahame DA, Krzycki JA (September 2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri" . The Journal of Biological Chemistry . 275 (37): 29053–60. doi :10.1074/jbc.m910218199 . PMID 10852929 .
External links
Activity Regulation Classification Kinetics Types