Notes: Due to COVID-19, the Pioneer Football League suspended the fall 2020 football season. Dayton and Marist opted out of the spring season. Presbyterian played a full PFL schedule, but was ineligible for the conference title, and its games were not counted in PFL standings.
Drake had a game scheduled against Hastings on September 3, which was later canceled before the start of the 2020 season.[1][2] A replacement game, scheduled for the same day, was announced against Black Hills State on July 14.[3] On July 27, that replacement game, along with Drake's scheduled games against North Dakota State and Dixie State, were canceled due to the Pioneer Football League's decision to play a conference-only schedule due to the COVID-19 pandemic.[4] In August, the entire schedule was pushed to spring due to the pandemic. On December 17, the PFL announced its revised spring football season schedule, which included Presbyterian, who were originally not scheduled to move into the PFL until the 2021–22 season.[5][6]
Following the decisions by Marist and Dayton to opt out of a spring season, the PFL released another schedule in February 2021.