The 2021 NCAA Men's Water Polo Championship occurred from December 4–5, 2021 in Los Angeles, California at the Spieker Aquatics Center. This was the 53rd NCAA Men's Water Polo Championship. Seven teams participated in this championship. Opening round game-one was played at Princeton University. The UCLA Bruins were the defending national champions and the 2021 Mountain Pacific Sports Federation (MPSF) champions. The rankings before the tournament: No. 1 University of California, No. 2 University of Southern California, No. 3 University of California Los Angeles, No. 4 Stanford University, No. 5 Long Beach State University.
The championship featured a knockout format where schools that lost were eliminated from the tournament. The championship pairings were announced on Sunday, November 21, 2021 by the NCAA Men’s Water Polo Committee.