The 2021–22 Montenegrin Second League was the 16th season since the establishment of the Montenegrin Second League. The season ran from August 2021 to May 2022. That was the fourth season with 10 participating teams.
This is the fourth season of Second CFL with 10 participants. At the end of the season, the winner is automatically promoted to Montenegrin First League, while 2nd and 3rd placed teams play promotion play-offs, while 9th and 10th position lead to relegation to the Montenegrin Third League.
The 3rd-placed team (against the 10th-placed team of the First League) and the runners-up (against the 11th-placed team of the First League) will both compete in two-legged promotion play-offs after the end of the season.