Angelique Kerber defeated Kaja Juvan in the final, 7–6(7–5), 6–7(0–7), 7–6(7–5) to win the singles tennis title at the 2022 Internationaux de Stasborg. It was her 14th WTA Tour singles title. The final lasted 3 hours and 16 minutes.
Barbora Krejčíková was the reigning champion, but withdrew before the tournament.
This was Samantha Stosur's final professional appearance in singles; she lost in the first round to Harmony Tan.