The 2024–25 EPCR Challenge Cup will be the eleventh edition of the EPCR Challenge Cup, an annual second-tier rugby union competition for professional clubs. Including the predecessor competition, the original European Challenge Cup, this is the 29th edition of European club rugby's second-tier competition.
Sixteen teams qualified for the 2024–25 EPCR Challenge Cup from Premiership Rugby, the Top 14 and the United Rugby Championship as a direct result of their domestic league performance having not qualified for the Champions Cup. Plus two invited sides totalling 18 teams.[2]