Encinas served in the cabinet of Andrés Manuel López Obrador (AMLO) until AMLO's resignation. He was the Head of Government of the Federal District from August 1, 2005, to December 4, 2006. He was succeeded by Marcelo Ebrard.
Encinas' provided official support for López Obrador's presidential campaign during the 2006 Mexican general election, and later support of the blockade of avenues in Mexico City.[citation needed]
He is also the Minister of Environment, Minister of Economic Development, Government Secretary and Head of Government of the Federal District.[2] He was appointed Secretary of the Interior on 16 June, 2023. [3]