Anaritide (also known as human atrial natriuretic peptide [102-126])[1] is a synthetic analogue of atrial natriuretic peptide[2] (ANP).
Anartidine has the following primary structure:[3]
or
H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
This structure is identical to residues 102-126 of human preproANP.[1][4] In comparison, active human ANP comprises resides 99-126 of human preproANP.[5]
Anaritide has been investigated as a potential therapy for acute tubular necrosis but was shown not to improve the dialysis-free survival of these patients.[2] It also appears to exacerbate proteinuria and natriuresis in patients with nephrotic syndrome.[6]