The marriage took place in October 1326.[4] She joined the Eastern Orthodox Church and took the name Anna.[6] In 1328, Andronikos III entered Constantinople and finally deposed his grandfather.[7]
Regent
On 14-15 June 1341, Andronikos III died.[8] He was succeeded by their son John V who was still three days short of his ninth birthday. Anna was appointed regent for her son.[9] However, Andronikos III had entrusted the administration to his advisor John Kantakouzenos, whom Anna did not trust.
On 26 October 1341, Kantakouzenos answered by proclaiming himself emperor at Didymoteicho. He still controlled part of the Byzantine army, and his claim to the throne began a civil war that lasted until 1347. Ivan Alexander of Bulgaria soon allied with the faction under John V and Anna while Stefan Uroš IV Dušan of Serbia sided with John VI. Both rulers were actually taking advantage of the civil war for their own political and territorial gains. In time John VI would ally himself with Orhan I of the nascent Ottoman emirate.
On 3 February 1347, the two sides reached an agreement. John VI was accepted as senior emperor with John V as his junior co-ruler.[11] The agreement included the marriage of John V to Helena Kantakouzene, a daughter of John VI.[12] John VI entered Constantinople and took effective control of the city.
Later years
In 1351, Anna left Constantinople for Thessaloniki. She held her own court in the city, issuing decrees in her name and even controlling a mint. She was the second Byzantine empress to hold court in Thessaloniki, following Irene of Montferrat. Her rule there lasted to about 1365.
Her last official act was the donation of a convent in the memory of Agioi Anargyroi (Greek: «Άγιοι Ανάργυροι» "The Angels Without Money"). Agioi Anargyroi is the joined description of Saints Cosmas and Damian, who supposedly
offered free medical services. Their devotees usually pray for healing. The donation may indicate Anna suffering from poor health and hoping for a cure. A little later she became a nun and died under the name "Anastasia" ca. 1365.
Italics indicates a consort to a junior co-emperor, underlining indicates a consort to an emperor variously regarded as either legitimate or a usurper, and bold incidates an empress regnant.