DiBlasi was born and raised in Boston, Massachusetts, where he graduated from film school at Emerson College.[1] While in the program, he held an internship with Marvel Studios in Los Angeles, California, around the time that the 2002 film Spider-Man was in post-production.[2] After a meeting with novelist and filmmaker Clive Barker and producer Joe Daley, DiBlasi was hired by Barker and Daley as an intern, and he soon began working with them on film projects full-time.[2] DiBlasi served as an executive producer on the horror films The Midnight Meat Train (2008) and Book of Blood (2009), each based on short stories by Barker.[1] DiBlasi made his directorial debut in 2009 with the film Dread, based on the 1984 short story of the same name by Barker.[1][2]
In 2014, DiBlasi directed the film Last Shift, which he co-wrote with Scott Poiley. A reboot of Last Shift, titled Malum, also directed by DiBlasi and written by DiBlasi and Poiley, is slated for release in 2023.[3]