Mazikou began his senior career with Lorient but was unable to break into the first-team. He managed just one appearance, playing full 90 minutes in a 3–2 away loss against Stade Rennais in the Coupe de la Ligue on 26 October 2016.[1]
Mazikou played two seasons regularly for Lorient B and spent time on loan at Dunkerque and Cholet in the Championnat National, before joining Bulgarian club CSKA Sofia on a three years deal.
Mazikou joined CSKA Sofia for an undisclosed fee on 20 August 2019.[2]
On 5 July 2022, Mazikou signed a three-year contract with Aris.[3]