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Christa Brosseau

Christa Brosseau
NationalityCanadian
TitleAssociate Professor and Canada Research Chair
Academic background
EducationDalhousie University
Alma materUniversity of Guelph
ThesisElectrochemical and PM-IRRAS studies of Cholera toxin binding at a model biological membrane (2007)
Doctoral advisorJacek Lipkowski
Academic work
DisciplineChemistry
InstitutionsSaint Mary's University, Northwestern University, Dalhousie University, University of Guelph
Main interestselectrochemistry, surface-enhanced Raman spectroscopy
Websitehttps://www.brosseaulab.com/

Christa L. Brosseau is a Canadian chemist, currently a Canada Research Chair at Saint Mary's University (Halifax). Brosseau's research focus is on Electrochemical Surface-Enhanced Raman Spectroscopy.[1]

Early career and education

Brosseau was born in Halifax, Nova Scotia, and received a B.Sc. degree in chemistry from Dalhousie University and a MSc degree in 2003 under the supervision of Prof. Sharon Roscoe at Acadia University for studying the adsorption of proteins on metallic surfaces using electrochemical methods.[2]

Graduate studies

In 2007, Brosseau completed a PhD at the University of Guelph under the supervision of Prof. Jacek Lipkowski on a project which involved using electrochemistry and infrared spectroscopy to probe the interaction of cholera toxin with a model biological membrane supported on an electrode surface.[3]

Postdoctoral studies

In 2007, Brosseau received an Andrew W. Mellon Foundation postdoctoral fellowship to work at Northwestern University under the supervision of Prof. Richard P. Van Duyne, in collaboration with the Art Institute of Chicago. This project used surface-enhanced Raman spectroscopy (SERS) to analyze colorants in historical textiles and paintings.[4]

Research

In 2009, Brosseau joined the Chemistry department at Saint Mary's University as an Assistant Professor, and was promoted to Associate Professor in 2014. Brosseau was named the Canada Research Chair in Sustainable Chemistry and Materials in 2016.[5][1]

The Brosseau research lab investigates the spectra observed when nanoparticles interact with light, to develop green molecular sensors.[6] A green synthesis of silver nanoparticles improved their surface-enhanced Raman spectroscopy.[6] Electrochemical surface-enhanced Raman spectroscopy (EC-SERS) was useful for analyzing non-heme protein adsorption at electrified interfaces.[7] The loading of gold nanoparticles onto nitrocellulose membranes was enhanced using vertical flow, achieving greater and more consistent signal.[8]

Brossard's early achievements include developing a rapid and precise analytical method for detecting uric acid in urine using EC-SERS for routine diagnosis of early eclampsia [9] and the rapid detection of melamine in milk using a portable and affordable EC-SERS system.[10] The SERS of turmeric allowed its detection at very low concentrations in historic pastels from the painter Mary Cassatt.[11]

Awards and honors

See also

References

  1. ^ a b "The Brossard Group". smu.ca/academics/departments/chemistry-faculty-and-staff-christa.html.
  2. ^ Wright, Jennifer E.I; Fatih, Khalid; Brosseau, Christa L.; Omanovic, Sasha; Roscoe, Sharon G. (2003-07-17). "l-Phenylalanine adsorption on Pt: electrochemical impedance spectroscopy and quartz crystal nanobalance studies". Journal of Electroanalytical Chemistry. 550–551: 41–51. doi:10.1016/S0022-0728(03)00026-3. ISSN 1572-6657.
  3. ^ Leitch, Jay; Brosseau, Christa; Roscoe, Sharon; Lipkowski, Jacek (February 2009). "Characterizing Changes in the Structure and Orientation of Supported Model Membranes upon Binding of Cholera Toxin". Biophysical Journal. 96 (3): 2976. Bibcode:2009BpJ....96..549L. doi:10.1016/j.bpj.2008.12.2976.
  4. ^ Brosseau, Christa L.; Rayner, Kari S.; Casadio, Francesca; Grzywacz, Cecily M.; Van Duyne, Richard P. (2009-09-01). "Surface-Enhanced Raman Spectroscopy: A Direct Method to Identify Colorants in Various Artist Media". Analytical Chemistry. 81 (17): 7443–7447. doi:10.1021/ac901219m. ISSN 0003-2700. PMID 19637904.
  5. ^ "Brosseau Lab".
  6. ^ a b Brossard, Christa; Lynk, T.P.; Clarke, O.J.R.; Kesavan, N. (2018). "Development of a Sustainable Plasmon-Enhanced Spectroelectrichemical Sensor using Avocado Pit (Persea Americana) Extract". Sensors and Actuators B: Chemical. 257: 270–277. doi:10.1016/j.snb.2017.10.137.
  7. ^ Brosseau, Christa; Karaballi, R.A.; Merchant, S.; Power, S.R. (2018). "Electrochemical Surface-Enhanced Raman Spectroscopy (EC-SERS) Study of the Interaction between Protein Aggregates and Biomimetic Membranes". Physical Chemistry Chemical Physics. 20 (6): 4513–4526. Bibcode:2018PCCP...20.4513K. doi:10.1039/C7CP06838G. PMID 29372919.
  8. ^ Brosseau, Christa; Clarke, O.J.R.; Goodall, B.L.; Hui, H.P.; Vats, N. (2018). "Development of a SERS-Based Rapid Vertical Flow Assay for Point-Of-Care Diagnostics". Analytical Chemistry. 89 (3): 1405–1410. doi:10.1021/acs.analchem.6b04710. PMID 28208248.
  9. ^ Zhao, Lili; Blackburn, Jonathan; Brosseau, Christa L. (2015-01-06). "Quantitative Detection of Uric Acid by Electrochemical-Surface Enhanced Raman Spectroscopy Using a Multilayered Au/Ag Substrate". Analytical Chemistry. 87 (1): 441–447. doi:10.1021/ac503967s. ISSN 0003-2700. PMID 25483146.
  10. ^ Brosseau, Christa; Robinson, A.; Harroun, S.; Bergman, J. (2012). "A Portable Electrochemical SERS system for Routine Spectroelectrochemical Analysis". Analytical Chemistry. 84 (3): 1760–4. doi:10.1021/ac2030078. PMID 22242894.
  11. ^ Brosseau, Christa; Rayner, K.; Casadio, F.; Grzywacz, C.M.; Van Duyne, R.P. (2009). "Surface-Enhanced Raman Spectroscopy: A Direct Method to Identify Colorants in Various Artist Media". Analytical Chemistry. 81 (17): 7443–7447. doi:10.1021/ac901219m. PMID 19637904.
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