Janssen played in the B-Youth team for her first club, RKSV Wittenhorst. In the summer of 2013, she joined SGS Essen of the German Bundesliga. In linking up with Essen she turned down offers from teams PSV/FC Eindhoven and AFC Ajax of the BeNe League.[3] On 8 September 2013 (1st Round), she made her club debut in a 3–3 draw vs BV Cloppenburg in the Bundesliga.[4] She scored her first goal in an Essen jersey on 3 November 2013 (7th Round) in the 5–1 win against Hoffenheim. In 2015, the Dutchwoman signed for English side Arsenal Ladies.[4] This move proved to be fruitful for her with Janssen winning the WSL Cup of 2015 in a 3–0 beating of Notts County by Arsenal.[5]
She once again played in another Cup final the following season, this being the 2016FA Cup final which took place on 14 May. Arsenal beat Chelsea by 1 goal to nil in the match at Wembley and were thus crowned champions, earning their fourteenth FA Cup title.[6][7]
Following the 2018–19 WSL season and 100 club appearances for Arsenal, Janssen signed with German Champions Wolfsburg.[8]
On 2 July 2024, Janssen signed for Manchester United on a three-year deal with the option to extend for a further year.[9]
International career
Dominique Janssen training with the Netherlands on 6 November 2018
Janssen played for the first time for a Junior selection of Royal Dutch Football Association on 17 March 2010 at the friendly match of U-15 national team against England. In 2012, she was captain of the Dutch U-17 team in the qualifying matches for the 2012 UEFA Women's Under-17 Championship and also led the team, as captain, in qualifying for the 2013 UEFA Women's Under-19 Championship.[10] In 2014, she succeeded with her team to qualify for the final round the 2014 UEFA Women's Under-19 Championship in Norway, where Netherlands won the title for the first time with 1–0 victory against Spain. Janssen played all five matches in the tournament.[11]
In 2014, she was called for the senior team for the first time, taking part in the Netherlands squad for the 2014 Cyprus Cup. On 5 March 2014 she made her debut, when she came off the bench in the 65th minute at 2–2 against Australia.[12]
In 2019, she was named to the squad for the 2019 World Cup.[16] The Netherlands won every match of the group stage and reached the final, where they lost to the United States. Janssen played in all seven of Leeuwinnen's games and didn't miss a minute. In the second group game against Cameroon, she scored her first international goal.
In the subsequent qualification for the 2022 European Championships, she played in nine out of ten games and scored one goal. With ten wins, the Dutch qualified for the finals, which were postponed by a year due to the COVID-19 pandemic. Because of the pandemic, the 2020 Olympic Games, for which the Dutch had qualified for the first time as runners-up in the World Cup, were also postponed by one year. Janssen was there in the victories against Zambia (10-3) and China (8-2) and in the 3-3 against Brazil, where she scored the goal to make it 3-3 final score, and lost on penalties against world champions USA in the quarterfinals. In the qualifying for the 2023 World Cup, she was used six times in the first seven games.
On 31 May 2022, she was nominated for the European Championship finals and completed all four games of the Dutch team there.[17] In the quarterfinals against France, a foul by Janssens in extra time led to France's decisive penalty goal.
In 2020, Janssen announced that she and Bloodworth had decided to split up and she reverted to using her maiden name.[21] She is in relationship with German former professional footballer Patrick Platins.