He married Christiana Emma Mudelle of Maidstone, Kent, England, in 1856, and they moved to South Africa, where they went on to have eight children, their eldest being Frederick Luke St Leger (1857 - 1938), another son Colonel Stratford Edward St Leger (1867-1935) was a member of the Royal Irish Regiment.[2] His granddaughter was the artist and poet Joan St Leger Lindbergh.
Hilton-Barber, David (2014). The Saint, the Surgeon and the Unsung Botanist: A tribute to my remarkable ancestors. Footprints Press. ISBN978-0-620-61401-6.