Bilateral relations between both nations have taken place primarily in multilateral forums. In November 2006 Guatemalan Vice-President Eduardo Stein attended the 16th Ibero-American Summit in Montevideo.[2] In November 2018 Uruguayan Vice-President Lucía Topolansky paid a visit to Antigua, Guatemala to attend the 26th Ibero-American Summit.[3]
Both nations have signed several agreements such as an Agreement on Scientific and Technical Cooperation (1987); Cultural Agreement (1987); Agreement on Economic and Commercial Cooperation (1987); Memorandum of Understanding on Political Consultations (2007); Agreement for the Exchange of Information Regarding the Design and Implementation of Drug Policies (2013); Agreement in Academic Cooperation (2013); and an Agreement on Trade and Investment (2019).[5]