Keller-Sutter undertook a political career as a municipal councillor in Wil between 1992 and 2000. She presided the municipal assembly in 1997. From 1996 to 2000, she was a deputy of the Kantonsrat of the canton of St. Gallen, while presiding the local arm of the FDP.
On 12 March 2000, Keller-Sutter was elected to the Regierungsrat of the canton of St. Gallen, where she was appointed to the department for security and justice. She was also vice president of the conference of cantonal directors for justice and police. She presided the government in 2006–2007.
On 8 October 2018, she once again announced her candidacy for Swiss Federal Council, this time for the seat of recently retired Schneider-Ammann, who had defeated her eight years before.[3] On 5 December 2018, she was elected for the Federal Council with 154 votes out of 237, alongside Viola Amherd of the Christian Democratic People's Party (CVP/PDC).[4]
Personal life
Keller-Sutter is married to Morton Keller, a doctor.[5]