List of human spaceflights, 1991–2000

This is a detailed list of human spaceflights from 1991 to 2000, including the continuation of Russian space station Mir and the American Space Shuttle program, and the first flights to the International Space Station (ISS).

The Soviet Union broke up at the end of 1991. From this date onwards the former USSR constituent republics are shown as separate nationalities.

#	Crew	Launch spacecraft	Habitation		Return spacecraft	Brief mission summary
141	Steven R. Nagel (3) Kenneth D. Cameron (1) Jerry L. Ross (3) Jerome Apt (1) Linda M. Godwin (1)	5 April 1991 STS-37, Atlantis		11 April 1991 STS-37, Atlantis		Deployment of Compton Gamma Ray Observatory.
142	Michael L. Coats (3) L. Blaine Hammond (1) Guion S. Bluford (3) Gregory J. Harbaugh (1) Richard J. Hieb (1) Donald R. McMonagle (1) Charles L. Veach (1)	28 April 1991 STS-39, Discovery		6 May 1991 STS-39, Discovery		U.S. Department of Defense mission. Part-classified payload, including various science experiments and observations.
143	Helen Sharman	18 May 1991 Soyuz TM-12	Mir		26 May 1991 Soyuz TM-11	Mir crew rotation. Life science experiments. First Briton in space (Sharman). First European woman in space (Sharman).
	Anatoli Artsebarsky				10 October 1991 Soyuz TM-12
	Sergei Krikalev (2)				25 March 1992 Soyuz TM-13
144	Bryan D. O'Connor (2) Sidney M. Gutierrez (1) James P. Bagian (2) Tamara E. Jernigan (1) M. Rhea Seddon (2) F. Drew Gaffney Millie E. Hughes-Fulford	5 June 1991 STS-40, Columbia		14 June 1991 STS-40, Columbia		Spacelab life sciences mission, studying humans, rodents and jellyfish.
145	John E. Blaha (3) Michael A. Baker (1) Shannon W. Lucid (3) James C. Adamson (2) G. David Low (2)	2 August 1991 STS-43, Atlantis		11 August 1991 STS-43, Atlantis		Deployment of Tracking and Data Relay Satellite-5.
146	John O. Creighton (3) Kenneth S. Reightler (1) James F. Buchli (4) Charles D. Gemar (2) Mark N. Brown (2)	12 September 1991 STS-48, Discovery		18 September 1991 STS-48, Discovery		Deployment of Upper Atmosphere Research Satellite (UARS).
147	Toktar Aubakirov Franz Viehböck	2 October 1991 Soyuz TM-13	Mir		10 October 1991 Soyuz TM-12	Mir crew rotation. First Kazakh in space (Aubakirov). First Austrian in space (Viehböck).
	Aleksandr Volkov (3)				25 March 1992 Soyuz TM-13
148	Frederick D. Gregory (3) Terence T. Henricks (1) F. Story Musgrave (4) Mario Runco (1) James S. Voss (1) Thomas J. Hennen	24 November 1991 STS-44, Atlantis		1 December 1991 STS-44, Atlantis		U.S. Department of Defense mission. Deployment of Defense Support Program (DSP) satellite.
149	Ronald J. Grabe (3) Stephen S. Oswald (1) Norman E. Thagard (4) David C. Hilmers (4) William F. Readdy (1) Roberta L. Bondar Ulf Merbold (2)	22 January 1992 STS-42, Discovery		30 January 1992 STS-42, Discovery		International Microgravity Laboratory-1 (IML-1). Life sciences and materials processing experiments. First Canadian woman in space (Bondar).
150	Klaus-Dietrich Flade	17 March 1992 Soyuz TM-14	Mir		25 March 1992 Soyuz TM-13	First Soyuz mission since the collapse of the USSR.
	Aleksandr Viktorenko (3) Aleksandr Kaleri (1)				10 August 1992 Soyuz TM-14
151	Charles F. Bolden (3) Brian Duffy (1) Kathryn D. Sullivan (3) David C. Leestma (3) C. Michael Foale (1) Byron K. Lichtenberg (2) Dirk Frimout	24 March 1992 STS-45, Atlantis		2 April 1992 STS-45, Atlantis		Atmospheric Laboratory for Applications and Science (ATLAS-1): international experiments in atmospheric and astronomical research. First Belgian in space (Frimout).
152	Daniel C. Brandenstein (4) Kevin P. Chilton (1) Pierre J. Thuot (2) Kathryn C. Thornton (2) Richard J. Hieb (2) Thomas D. Akers (2) Bruce E. Melnick (2)	7 May 1992 STS-49, Endeavour		16 May 1992 STS-49, Endeavour		Retrieval and redeployment of INTELSAT VI (F-3) satellite. Demonstration of maintenance and assembly capabilities for Space Station Freedom.
153	Richard N. Richards (3) Kenneth D. Bowersox (1) Bonnie J. Dunbar (3) Lawrence J. DeLucas Ellen S. Baker (2) Carl J. Meade (2) Eugene H. Trinh	25 June 1992 STS-50, Columbia		9 July 1992 STS-50, Columbia		United States Microgravity Laboratory-I (USML-1): various microgravity experiments.
154	Michael Tognini (1)	27 July 1992 Soyuz TM-15	Mir		10 August 1992 Soyuz TM-14	Mir crew rotation.
	Anatoly Solovyev (3) Sergei Avdeyev (1)				1 February 1993 Soyuz TM-15
155	Loren J. Shriver (3) Andrew M. Allen (1) Jeffrey A. Hoffman (3) Franklin R. Chang-Diaz (3) Claude Nicollier (1) Marsha S. Ivins (2) Franco Malerba	31 July 1992 STS-46, Atlantis		8 August 1992 STS-46, Atlantis		Deployment of ESA's EURECA (European Retrievable Carrier). Deployment of joint NASA/Italian Space Agency Tethered Satellite System (TSS) (failed). First Swiss in space (Nicollier). First Italian in space (Malerba).
156	Robert L. Gibson (4) Curtis L. Brown (1) Mark C. Lee (2) N. Jan Davis (1) Jerome Apt (2) Mae C. Jemison Mamoru Mohri (1)	12 September 1992 STS-47, Endeavour		20 September 1992 STS-47, Endeavour		50th Space Shuttle mission. Joint NASA and NASDA mission. Conducted microgravity investigations in materials and life sciences. First African-American woman in space (Jemison).
157	James B. Wetherbee (2) Michael A. Baker (2) Charles L. Veach (2) William M. Shepherd (3) Tamara E. Jernigan (2) Steven G. MacLean (1)	22 October 1992 STS-52, Columbia		1 November 1992 STS-52, Columbia		Deployment of Laser Geodynamic Satellite II (LAGEOS-II). US Microgravity Payload-1 (USMP-1): physics experiments.
158	David M. Walker (3) Robert D. Cabana (2) Guion S. Bluford (4) James S. Voss (2) Michael R. Clifford (1)	2 December 1992 STS-53, Discovery		9 December 1992 STS-53, Discovery		Classified US Department of Defense primary payload, reportedly a reconnaissance satellite. Miscellaneous unclassified science experiments.
159	John H. Casper (2) Donald R. McMonagle (2) Mario Runco (2) Gregory J. Harbaugh (2) Susan J. Helms (1)	13 January 1993 STS-54, Endeavour		19 January 1993 STS-54, Endeavour		Deployment of fifth Tracking and Data Relay Satellite (TDRS-F). Diffuse X-ray Spectrometer (DXS) and microgravity experiments.
160	Gennadi Manakov (2) Aleksandr Poleshchuk	24 January 1993 Soyuz TM-16	Mir		22 July 1993 Soyuz TM-16	Docking system tests.
161	Kenneth D. Cameron (2) Stephen S. Oswald (2) C. Michael Foale (2) Kenneth D. Cockrell (1) Ellen L. Ochoa (1)	8 April 1993 STS-56, Discovery		17 April 1993 STS-56, Discovery		Atmospheric Laboratory for Applications and Science-2 (ATLAS-2). Atmospheric and solar science research.
162	Steven R. Nagel (4) Terence T. Henricks (2) Jerry L. Ross (4) Charles J. Precourt (1) Bernard A. Harris (1) Ulrich Walter Hans Schlegel (1)	26 April 1993 STS-55, Columbia		6 May 1993 STS-55, Columbia		German-sponsored Spacelab flight: miscellaneous science experiments.
163	Ronald J. Grabe (4) Brian Duffy (2) G. David Low (3) Nancy J. Sherlock Currie (1) Peter J. Wisoff (1) Janice E. Voss (1)	21 June 1993 STS-57, Endeavour		1 July 1993 STS-57, Endeavour		First SPACEHAB flight: biomedical and materials sciences experiments. Retrieval of ESA's EURECA (European Retrievable Carrier).
164	Jean-Pierre Haigneré (1)	1 July 1993 Soyuz TM-17	Mir		22 July 1993 Soyuz TM-16	Mir crew rotation.
	Vasili Tsiblyev (1) Aleksandr Serebrov (4)				13 January 1994 Soyuz TM-17
165	Frank L. Culbertson (2) William F. Readdy (2) James H. Newman (1) Daniel W. Bursch (1) Carl E. Walz (1)	12 September 1993 STS-51, Discovery		22 September 1993 STS-51, Discovery		Deployment of Advanced Communications Technology Satellite (ACTS). Ultraviolet astronomical observations.
166	John E. Blaha (4) Richard A. Searfoss (1) M. Rhea Seddon (3) William S. McArthur (1) David A. Wolf (1) Shannon W. Lucid (4) Martin J. Fettman	18 October 1993 STS-58, Columbia		1 November 1993 STS-58, Columbia		Spacelab life sciences mission.
167	Richard O. Covey (4) Kenneth D. Bowersox (2) F. Story Musgrave (5) Kathryn C. Thornton (3) Claude Nicollier (2) Jeffrey A. Hoffman (4) Thomas D. Akers (3)	2 December 1993 STS-61, Endeavour		13 December 1993 STS-61, Endeavour		First Hubble Space Telescope repair servicing mission.
168	Viktor Afanasyev (2) Yuri Usachyev (1)	8 January 1994 Soyuz TM-18	Mir		9 July 1994 Soyuz TM-18	Mir crew rotation.
	Valeri Polyokov (2)				22 March 1995 Soyuz TM-20
169	Charles F. Bolden (4) Kenneth S. Reightler (2) N. Jan Davis (2) Ronald M. Sega (1) Franklin R. Chang-Diaz (4) Sergei Krikalev (3)	3 February 1994 STS-60, Discovery		11 February 1994 STS-60, Discovery		SPACEHAB-2: materials science and life sciences investigations. Wake Shield Facility-1 deployment. Medical and radiological investigations. First Russian to fly aboard the Space Shuttle (Krikalev).
170	John H. Casper (3) Andrew M. Allen (2) Pierre J. Thuot (3) Charles D. Gemar (3) Marsha S. Ivins (3)	4 March 1994 STS-62, Columbia		18 March 1994 STS-62, Columbia		Miscellaneous scientific experiments.
171	Sidney M. Gutierrez (2) Kevin P. Chilton (2) Linda M. Godwin (2) Jerome Apt (3) Michael R. Clifford (2) Thomas D. Jones (1)	9 April 1994 STS-59, Endeavour		20 April 1994 STS-59, Endeavour		Radar mapping of Earth and atmospheric research.
172	Yuri Malenchenko (1) Talgat Musabayev (1)	3 July 1994 Soyuz TM-19	Mir		4 November 1994 Soyuz TM-19	Medical and materials science experiments. Mir repairs.
173	Robert D. Cabana (3) James D. Halsell (1) Richard J. Hieb (3) Carl E. Walz (2) Leroy Chiao (1) Donald A. Thomas (1) Chiaki Naito-Mukai (1)	8 July 1994 STS-65, Columbia		23 July 1994 STS-65, Columbia		International Microgravity Laboratory-2: miscellaneous microgravity experiments. First Japanese woman in space (Naito-Mukai).
174	Richard N. Richards (4) L. Blaine Hammond (2) Jerry M. Linenger (1) Susan J. Helms (2) Carl J. Meade (3) Mark C. Lee (3)	9 September 1994 STS-64, Discovery		20 September 1994 STS-64, Discovery		Atmospheric and solar observations.
175	Michael A. Baker (3) Terrence W. Wilcutt (1) Thomas D. Jones (2) Steven L. Smith (1) Daniel W. Bursch (2) Peter J.K. Wisoff (2)	30 September 1994 STS-68, Endeavour		11 October 1994 STS-68, Endeavour		Radar imaging of Earth.
176	Ulf Merbold (3)	4 October 1994 Soyuz TM-20	Mir		4 November 1994 Soyuz TM-19	Mir crew rotation.
	Aleksandr Viktorenko (4) Yelena Kondakova (1)				22 March 1995 Soyuz TM-20
177	Donald R. McMonagle (3) Curtis L. Brown (2) Ellen L. Ochoa (2) Scott E. Parazynski (1) Joseph R. Tanner (1) Jean-François Clervoy (1)	3 November 1994 STS-66, Atlantis		14 November 1994 STS-66, Atlantis		Atmospheric research.
178	James D. Wetherbee (3) Eileen M. Collins (1) C. Michael Foale (3) Janice E. Voss (2) Bernard A. Harris (2) Vladimir G. Titov (3)	3 February 1995 STS-63, Discovery		11 February 1995 STS-63, Discovery		Rendezvous maneuver with Mir. First female pilot (Collins). SPACEHAB-3: miscellaneous science experiments. First EVA by an African-American astronaut (Harris).
179	Stephen S. Oswald (3) William G. Gregory Tamara E. Jernigan (3) John M. Grunsfeld (1) Wendy B. Lawrence (1) Ronald A. Parise (2) Samuel T. Durrance (2)	2 March 1995 STS-67, Endeavour		18 March 1995 STS-67, Endeavour		Ultraviolet astronomy studies.
180	Norman E. Thagard (5) Vladimir Dezhurov (1) Gennady Strekalov (5)	14 March 1995 Soyuz TM-21	Mir		7 July 1995 STS-71, Atlantis	First American to visit Mir (Thagard).
181	Robert L. Gibson (5) Charles J. Precourt (2) Ellen S. Baker (3) Bonnie J. Dunbar (4) Gregory J. Harbaugh (3)	27 June 1995 STS-71, Atlantis	Mir		7 July 1995 STS-71, Atlantis	First Shuttle-Mir docking. Biomedical experiments. Mir crew rotation and resupply.
	Anatoly Solovyev (4) Nikolai Budarin (1)				11 September 1995 Soyuz TM-21
182	Terence T. Henricks (3) Kevin R. Kregel (1) Nancy J. Sherlock Currie (2) Donald A. Thomas (2) Mary E. Weber (1)	13 July 1995 STS-70, Discovery		22 July 1995 STS-70, Discovery		Deployment of 7th Tracking and Data Relay Satellite (TDRS). Biological and biomedical studies.
183	Sergei Avdeyev (2) Yuri Ghidzenko (1) Thomas Reiter (1)	3 September 1995 Soyuz TM-22	Mir		29 February 1996 Soyuz TM-22	Mir crew rotation. First EVA by a German cosmonaut (Reiter).
184	David M. Walker (4) Kenneth D. Cockrell (2) James S. Voss (3) James H. Newman (2) Michael L. Gernhardt (1)	7 September 1995 STS-69, Endeavour		18 September 1995 STS-69, Endeavour		Solar observations. Wake Shield Facility-2 deployment.
185	Kenneth D. Bowersox (3) Kent V. Rominger (1) Kathryn C. Thornton (4) Catherine G. Coleman (1) Michael E. Lopez-Alegria (1) Fred W. Leslie Albert Sacco	20 October 1995 STS-73, Columbia		5 November 1995 STS-73, Columbia		Microgravity experiments.
186	Kenneth D. Cameron (3) James D. Halsell (2) Jerry L. Ross (5) William S. McArthur (2) Chris A. Hadfield (1)	12 November 1995 STS-74, Atlantis	Mir		20 November 1995 STS-74, Atlantis	Second Shuttle-Mir docking. Delivery of Russian docking module and solar arrays.
187	Brian Duffy (3) Brent W. Jett (1) Leroy Chiao (2) Daniel T. Barry (1) Winston E. Scott (1) Koichi Wakata (1)	11 January 1996 STS-72, Endeavour		20 January 1996 STS-72, Endeavour		Capture and return to Earth of Space Flyer Unit (Japanese microgravity research spacecraft).
188	Yuri Onufrienko (1) Yuri Usachyev (2)	21 February 1996 Soyuz TM-23	Mir		2 September 1996 Soyuz TM-23
189	Andrew M. Allen (3) Scott J. Horowitz (1) Franklin R. Chang-Diaz (5) Maurizio Cheli Jeffrey A. Hoffman (5) Claude Nicollier (3) Umberto Guidoni (1)	22 February 1996 STS-75, Columbia		9 March 1996 STS-75, Columbia		Deployment of Tethered Satellite System (TSS-1R) (reflight, partial success). Microgravity research.
190	Kevin P. Chilton (3) Richard A. Searfoss (2) Linda M. Godwin (3) Michael R. Clifford (3) Ronald M. Sega (2)	22 March 1996 STS-76, Atlantis	Mir		31 March 1996 STS-76, Atlantis	Mir crew rotation and resupply. First American woman on Mir (Lucid).
	Shannon W. Lucid (5)				26 September 1996 STS-79, Atlantis
191	John H. Casper (4) Curtis L. Brown (3) Daniel W. Bursch (3) Mario Runco, Jr. (3) J. Marc Garneau (2) Andrew S.W. Thomas (1)	19 May 1996 STS-77, Endeavour		29 May 1996 STS-77, Endeavour		SPACEHAB-4: miscellaneous science experiments. Deployment of Spartan-207/IAE (Inflatable Antenna Experiment) satellite. Rendezvous with experimental satellite.
192	Terence T. Henricks (4) Kevin R. Kregel (2) Susan J. Helms (3) Richard M. Linnehan (1) Charles E. Brady Jean-Jacques Favier Robert B. Thirsk (1)	20 June 1996 STS-78, Columbia		7 July 1996 STS-78, Columbia		Microgravity, human physiology and life sciences research.
193	Claudie Haigneré (1)	18 August 1996 Soyuz TM-24	Mir		2 September 1996 Soyuz TM-23	Mir crew rotation. Biological and medical experiments. First Frenchwoman in space (Andre-Deshays).
	Valery Korzun (1) Aleksandr Kaleri (2)				2 March 1997 Soyuz TM-24
194	William F. Readdy (3) Terrence W. Wilcutt (2) Thomas D. Akers (4) Jerome Apt (4) Carl E. Walz (3)	16 September 1996 STS-79, Atlantis	Mir		26 September 1996 STS-79, Atlantis	Mir crew rotation and resupply. Miscellaneous scientific experiments.
	John E. Blaha (5)				22 January 1997 STS-81, Atlantis
195	Kenneth D. Cockrell (3) Kent V. Rominger (2) Tamara E. Jernigan (4) Thomas D. Jones (3) F. Story Musgrave (6)	19 November 1996 STS-80, Columbia		7 December 1996 STS-80, Columbia		Deployment and retrieval of Wake Shield Facility and German-built Orbiting and Retrievable Far and Extreme Ultraviolet Spectrograph-Shuttle Pallet Satellite II (ORFEUS-SPAS II).
196	Michael A. Baker (4) Brent W. Jett (2) John M. Grunsfeld (2) Marsha S. Ivins (4) Peter J.K. Wisoff (3)	12 January 1997 STS-81, Atlantis	Mir		22 January 1997 STS-81, Atlantis	Mir crew rotation and resupply.
	Jerry M. Linenger (2)				24 May 1997 STS-84, Atlantis
197	Reinhold Ewald	10 February 1997 Soyuz TM-25	Mir		2 March 1997 Soyuz TM-24	Mir crew rotation and resupply.
	Vasili Tsibliev (2) Aleksandr Lazutkin				14 August 1997 Soyuz TM-25
198	Kenneth D. Bowersox (4) Scott J. Horowitz (2) Mark C. Lee (4) Steven A. Hawley (4) Gregory J. Harbaugh (4) Steven L. Smith (2) Joseph R. Tanner (2)	11 February 1997 STS-82, Discovery		21 February 1997 STS-82, Discovery		Hubble Space Telescope servicing mission.
199	James D. Halsell (3) Susan L. Still (1) Janice E. Voss (3) Donald A. Thomas (3) Michael L. Gernhardt (2) Roger K. Crouch (1) Gregory T. Linteris (1)	4 April 1997 STS-83, Columbia		8 April 1997 STS-83, Columbia		Microgravity experiments. Mission cut short due to fuel cell problems.
200	Charles J. Precourt (3) Eileen M. Collins (2) Jean-François Clervoy (2) Carlos I. Noriega (1) Edward T. Lu (1) Yelena Kondakova (2)	15 May 1997 STS-84, Atlantis	Mir		24 May 1997 STS-84, Atlantis	Mir crew rotation and resupply. First joint US-Russian space walk.
	C. Michael Foale (4)				6 October 1997 STS-86, Atlantis
201	James D. Halsell (4) Susan L. Still (2) Janice E. Voss (4) Donald A. Thomas (4) Michael L. Gernhardt (3) Roger K. Crouch (2) Gregory T. Linteris (2)	1 July 1997 STS-94, Columbia		17 July 1997 STS-94, Columbia		Microgravity experiments. Reflight of curtailed STS-83 mission.
202	Anatoly Solovyev (5) Pavel Vinogradov (1)	6 August 1997 Soyuz TM-26	Mir		19 February 1998 Soyuz TM-26	Mir repair.
203	Curtis L. Brown (4) Kent V. Rominger (3) N. Jan Davis (3) Robert L. Curbeam (1) Stephen K. Robinson (1) Bjarni V. Tryggvason	7 August 1997 STS-85, Discovery		19 August 1997 STS-85, Discovery		Atmospheric research.
204	James D. Wetherbee (4) Michael J. Bloomfield (1) Vladimir Titov (4) Scott E. Parazynski (2) Jean-Loup Chrétien (3) Wendy B. Lawrence (2)	25 September 1997 STS-86, Atlantis	Mir		6 October 1997 STS-86, Atlantis	Mir crew rotation and resupply.
	David A. Wolf (2)				31 January 1998 STS-89, Endeavour
205	Kevin R. Kregel (3) Steven W. Lindsey (1) Winston E. Scott (2) Kalpana Chawla (1) Takao Doi (1) Leonid Kadeniuk	19 November 1997 STS-87, Columbia		5 December 1997 STS-87, Columbia		Miscellaneous scientific experiments. First Japanese EVA (Doi). First Ukrainian in space (Kadenyuk).
206	Terrence W. Wilcutt (3) Joe F. Edwards Bonnie J. Dunbar (5) Michael P. Anderson (1) James F. Reilly (1) Salizhan Sharipov (1)	22 January 1998 STS-89, Endeavour	Mir		31 January 1998 STS-89, Endeavour	Mir crew rotation and resupply.
	Andrew S.W. Thomas (2)				12 June 1998 STS-91, Discovery
207	Léopold Eyharts (1)	29 January 1998 Soyuz TM-27	Mir		19 February 1998 Soyuz TM-26	Mir crew rotation.
	Talgat Musabayev (2) Nikolai Budarin (2)				25 August 1998 Soyuz TM-27
208	Richard A. Searfoss (3) Scott D. Altman (1) Richard M. Linnehan (2) Dafydd R. Williams (1) Kathryn P. Hire (1) Jay C. Buckley James A. Pawelzyk	17 April 1998 STS-90, Columbia		3 May 1998 STS-90, Columbia		Neuroscience research. Final Spacelab mission.
209	Charles J. Precourt (4) Dominic L. Pudwill Gorie (1) Wendy B. Lawrence (3) Franklin R. Chang-Diaz (6) Janet L. Kavandi (1) Valery Ryumin (4)	2 June 1998 STS-91, Discovery	Mir		12 June 1998 STS-91, Discovery	Final Shuttle-Mir docking. Mir crew rotation and resupply. Astrophysics research.
210	Yuri Baturin (1)	15 August 1998 Soyuz TM-28	Mir		25 August 1998 Soyuz TM-27	Mir crew rotation.
	Gennady Padalka (1)				28 February 1999 Soyuz TM-28
	Sergei Avdeyev (3)				28 August 1999 Soyuz TM-29
211	Curtis L. Brown (5) Steven W. Lindsey (2) Scott E. Parazynski (3) Stephen K. Robinson (2) Pedro Duque (1) Chiaki Mukai (2) John H. Glenn (2)	29 October 1998 STS-95, Discovery		7 November 1998 STS-95, Discovery		Miscellaneous scientific experiments. First Spaniard in space (Duque). Veteran John Glenn returned to space aged 77.
212	Robert D. Cabana (4) Frederick W. Sturckow (1) Nancy J. Sherlock Currie (3) Jerry L. Ross (6) James H. Newman (3) Sergei Krikalev (4)	4 December 1998 STS-88, Endeavour	ISS		15 December 1998 STS-88, Endeavour	First ISS construction mission. Delivery of Unity Node Module.
213	Ivan Bella	20 February 1999 Soyuz TM-29	Mir		28 February 1999 Soyuz TM-28	Mir crew rotation. First Slovak in space (Bella).
	Viktor Afanasyev (3) Jean-Pierre Haigneré (2)				28 August 1999 Soyuz TM-29
214	Kent V. Rominger (4) Rick D. Husband (1) Ellen L. Ochoa (3) Tamara E. Jernigan (5) Daniel T. Barry (2) Julie Payette (1) Valery Tokarev (1)	27 May 1999 STS-96, Discovery	ISS		6 June 1999 STS-96, Discovery	Second ISS flight. ISS assembly and resupply.
215	Eileen M. Collins (3) Jeffrey S. Ashby (1) Steven A. Hawley (5) Catherine G. Coleman (2) Michel Tognini (2)	23 July 1999 STS-93, Columbia		27 July 1999 STS-93, Columbia		Deployment of Chandra X-ray Observatory. First female Shuttle Commander (Collins).
216	Curtis L. Brown (6) Scott J. Kelly (1) Steven L. Smith (3) C. Michael Foale (5) John M. Grunsfeld (3) Claude Nicollier (4) Jean-François Clervoy (3)	19 December 1999 STS-103, Discovery		27 December 1999 STS-103, Discovery		Hubble Space Telescope servicing.
217	Kevin R. Kregel (4) Dominic L. Pudwill Gorie (2) Janet L. Kavandi (2) Janice E. Voss (5) Mamoru Mohri (2) Gerhard Thiele	11 February 2000 STS-99, Endeavour		22 February 2000 STS-99, Endeavour		Radar topographic mapping of Earth's surface.
218	Sergei Zalyotin (1) Aleksandr Kaleri (3)	4 April 2000 Soyuz TM-30	Mir		16 June 2000 Soyuz TM-30	Mir repairs. 39th and final Mir mission.
219	James D. Halsell (5) Scott J. Horowitz (3) Mary E. Weber (2) Jeffrey N. Williams (1) James S. Voss (4) Susan J. Helms (4) Yuri Usachev (3)	19 May 2000 STS-101, Atlantis	ISS		29 May 2000 STS-101, Atlantis	ISS construction and supply.
220	Terrence W. Wilcutt (4) Scott D. Altman (2) Daniel C. Burbank (1) Edward T. Lu (2) Richard A. Mastracchio (1) Yuri Malenchenko (2) Boris Morukov	8 September 2000 STS-106, Atlantis	ISS		19 September 2000 STS-106, Atlantis	ISS supply. Preparation for first long-term crew.
221	Brian Duffy (4) Pamela A. Melroy (1) Koichi Wakata (2) Leroy Chiao (3) Peter J.K. Wisoff (4) Michael E. Lopez-Alegria (2) William S. McArthur (3)	11 October 2000 STS-92, Discovery	ISS		24 October 2000 STS-92, Discovery	ISS construction and outfitting. 100th Space Shuttle mission.
222	Yuri Gidzenko (2) Sergei Krikalev (5) William M. Shepherd (4)	31 October 2000 Soyuz TM-31	ISS (crew 1)		21 March 2001 STS-102, Discovery	First ISS Expedition Crew.
223	Brent W. Jett (3) Michael J. Bloomfield (2) Joseph R. Tanner (3) J. Marc Garneau (3) Carlos I. Noriega (2)	30 November 2000 STS-97, Endeavour	ISS		11 December 2000 STS-97, Endeavour	ISS construction and supply. Delivery of the first set of solar arrays and batteries.

• List of human spaceflight programs
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