Prince Marco's mother, the previous heiress to the dukedom of Medinaceli, predeceased her mother in 2012. He succeeded as duke when his grandmother, the 18th Duchess of Medinaceli, died in 2013.[2][3] He preserved his family's cultural heritage as director of the Fundación Medinaceli.
In 1996, he married a German citizen, Sandra Schmidt-Polex, by whom he had two children: