On 30 August 2011, Sampirisi joined Genoa in a 4-year contract.[2] He was exchanged with Pelé. Half of Sampirisi's registration rights was "valued" €1,000,000 and Pelé for €950,000.[3] Samprisi made his Serie A debut for Genoa on 22 January 2012 in a game against Palermo when he came on as a substitute in the 45th minute for Juraj Kucka.[4] In June 2012, AC Milan signed Pelé (€900,000) and Chinellato outright (€1,750,000); while Genoa acquired Nicola Pasini (€1,650,000) and Sampirisi outright (€1,000,000).[5] Circa 2012 he signed a new 4-year contract with Genoa (last until 30 June 2016).[6]
On 14 September 2014, he was signed by Serie B newcomer Vicenza in a temporary deal.[9][10] He scored an own goal in the return leg of the semi-finals of the promotion playoffs.[11] On 10 July 2015 Vicenza re-signed Sampirisi in a temporary deal, with an obligation to sign him outright.[12]
Crotone
In July 2016, Sampirisi was signed by Crotone on a free transfer.[13]
Monza
In July 2019, Sampirisi was signed by Monza on a free transfer. On 15 December 2020, Sampirisi scored a brace in the Serie B against Virtus Entella, helping Monza win 5–0.[14] He was subbed on in the 80th minute, scoring a first-touch long-range goal in the 82nd minute, and another in the 90th minute.[15] His two goals were his first in the competition.[16]
Sampirisi helped Monza gain promotion to the Serie A for the first time as their captain in 2021–22. He played 77 games and scored six goals, and was key to helping Monza gain promotions to the Serie B and Serie A.[17]
Loan to Frosinone
On 24 August 2022, Sampirisi was loaned to Serie B club Frosinone.[17]
Reggiana
On 27 August 2023, Sampirisi moved to Reggiana.[18]