Drayne is from Lisburn, County Antrim.[2][3] She is the daughter of Michael and Stella Drayne. She has four siblings Niamh, Maeve, Owen and Aideen.[4] Her mother, Stella Drayne, is a former netball coach/team manager with both Larkfield and Northern Ireland under-21 teams. She has coached teams that have included her daughter.[5][6][7] Michael Drayne is a dairy farmer and a partner in the family firm, Draynes Farm.[8][9] Michael and Stella Drayne have also fronted various sports sponsorships on behalf of Draynes Farm. These include Lisburn's Sports Personality of the Year Awards. Draynes Farm also helped sponsor the Northern Ireland team at the 2017 Netball World Youth Cup.[10][11] Drayne was educated at St. Joseph's Primary School in Lisburn [12] and at
Rathmore Grammar School.[13][14][15] Between 2007 and 2010 she attended Loughborough University where she gained a BSc in Sports Science and Management and an M.Ed./PGCE in Physical Education.[16][17][18]
Drayne has played ladies' Gaelic football at club level for St. Gall's.[39][48] In 2010 she helped St. Gall's win the Ulster Intermediate Club Ladies Football Championship and was named player of the match in the final [49]