The village was first mentioned in the 16th century. During the Ottoman rule (16th-17th century), it was populated by ethnic Serbs. From 1699, it was under Habsburg rule, and was part of the Habsburg Military Frontier (Šajkaš Battalion). From 1848 to 1849, Mošorin was part of Serbian Vojvodina, a Serbian autonomous region within the Austrian Empire, but from 1849, it was again part of the Military Frontier until 1873, when it was included into the Bačka-Bodrog County.
From 1918, Mošorin was part of the Kingdom of Serbs, Croats and Slovenes (later known as Yugoslavia). Between 1918 and 1922 it was part of the Bačka County, between 1922 and 1929 part of the Belgrade Oblast, and between 1929 and 1941 part of the Danube Banovina.
In 1941, the village was occupied by Axis troops and attached to Horthy's Hungary. In a 1942 raid, performed on OrthodoxChristmas, the Hungarian troops killed 205 villagers, including 94 men, 41 women, 44 children and 26 elderly, of whom 170 were Serbs, 34 Romani, and 1 Hungarian. Some of the corpses of the killed villagers were thrown into the icy waters of the river Tisa, while some were buried into four mass graves.
Isidora Sekulić (1877–1958), a famous Serbian literate, academic
Dušan Kanazir (1921–2009), a Serbian molecular biologist
Mladen Dražetin (1951–2015), Doctor of Social Sciences, intellectual, economist, theatrical creator, poet, writer and philosopher. He was born and died in Novi Sad, but spent part of his childhood in Mošorin, where his father Rada is from originally.