The route starts at a junction with National Cycle Route 754 at the Kelvin Aqueduct, then follows the Kelvin Walkway/Cycleway past Maryhill, Kirklee, Botanic Gardens and Kelvinbridge, to Kelvingrove Park.
Kelvingrove to Anderston
From Kelvingrove Park the route follows the Sustrans Connect2 Glasgow route to Anderston Cross, where it passes the end of the Anderston Bridge, then crosses the adjacent Stobcross Bridge, to follow a path down to Anderston Quay.
From Richmond Park the route passes Shawfield Stadium, following the Glasgow Road corridor, then passes through Rutherglen town centre. It then runs to the east of Mill Street, passing through Overtoun Park, then climbs up to Cathkin.
From Nerston, the route skirts Kingsgate Retail Park then heads down Mavor Avenue to join the course of an old railway line which it follows towards East Kilbride Village, then ends at the railway station in East Kilbride.