The highway starts at Rampur Malhaniya near the Indo-Nepal border and runs towards Rajbiraj where the first section of this highway terminates after connecting to NH05. The other section starts at Beriyar in Kanchanrup Municipality seprating from Highway NH-5 and runs towards Phattepur on Madhesh-Koshi border. From the Madhesh-Koshi border it enters to Udayapur District and runs towards Basaha where it finally merges with NH03.