What is now Ozone was once situated along the stage route built in the late 18th century between Knoxville and Nashville. Around 1806, the widow of Elijah Haley, an early Cumberland settler, established a tavern in the Ozone area, and would later be instrumental in the establishment of Crab Orchard Inn a few miles to the west. A small community grew up in the tavern's vicinity, although it consisted of only a few families. In 1880, when a post office was established, the community adopted the name "Mammy" after a nearby creek. In 1896, the community of Mammy changed its name to "Ozone," which referred to the area's excellent air quality.[4]
Ozone is where Myles Horton began his practice as a popular educator in 1927, helping poor people in Ozone talk out their problems and find solutions together. This deeply informed his organizing practice and helped lead to his founding the Highlander School.[5]