Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2gene.[5][6]
Function
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini.[5]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
^Pavloff N, Rivard D, Masson S, Shen SH, Mes-Masson AM (1992). "Sequence analysis of the large and small subunits of human ribonucleotide reductase". DNA Seq. 2 (4): 227–34. doi:10.3109/10425179209020807. PMID1627826.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243. S2CID14294292.
1h0o: COBALT SUBSTITUTION OF MOUSE R2 RIBONUCLEOTIDE REDUCTASE TO MODEL THE REACTIVE DIFERROUS STATE
1w68: CRYSTAL STRUCTURE OF MOUSE RIBONUCLEOTIDE REDUCTASE SUBUNIT R2 UNDER OXIDIZING CONDITIONS. A FULLY OCCUPIED DINUCLEAR IRON CLUSTER.
1xsm: PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE FROM MOUSE
1w69: CRYSTAL STRUCTURE OF MOUSE RIBONUCLEOTIDE REDUCTASE SUBUNIT R2 UNDER REDUCING CONDITIONS. A FULLY OCCUPIED DINUCLEAR IRON CLUSTER AND BOUND ACETATE.
1h0n: COBALT SUBSTITUTION OF MOUSE R2 RIBONUCLEOTIDE REDUCTASE TO MODEL THE REACTIVE DIFERROUS STATE
2uw2: CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE SUBUNIT R2
