In 1936 some adjacent districts of Multan and the State of Bahawalpur were detached from Lahore to form the prefecture Apostolic of Multan. In 1939 this area was detached from Lahore to become a separate diocese. In 1960 the diocese was divided and Bishop Cialeo moved to Faisalabad as the first bishop of the newly erected diocese of Faisalabad. Bishop Louis Scheerer was appointed the second bishop of Multan. In 1966 Bishop Louis Scheerer died and Bertrand Boland became the Bishop of Multan diocese. In 1984 Bishop Boland retired and handed over to his auxiliary Bishop Patras Yusaf. The diocese is a suffragan of the Archdiocese of Lahore.
On 3 October 1989, Pope John Paul II sent congratulations on the 50th anniversary of the diocese. The diocese had 10 parishes with about 50,000 Catholics at the time.[3] By June 2008 this had grown to 18 parishes.[4]
On 17 September 1998, Pope John Paul II appointed Father Raymond Saeed apostolic administrator for the Diocese.[5]
On 10 January 2000, Pope John Paul II proclaimed Fr. Andrew Francis from the Archdiocese of Lahore as the new bishop.[6]
On 29 October 2001 four gunmen entered St. Dominic's Church, Bahawalpur in the Diocese and shot and killed 15 worshippers and a police guard.[7]
On 29 April 2010 Pope Benedict XVI elevated the Apostolic Prefecture of Quetta to the rank of apostolic vicariate. He appointed Fr. Victor Gnanapragasam as apostolic vicar of the new ecclesiastical circumscription and the titular bishop of Timida.[8] Fr. Victor was parish priest at Khanewal in the Multan Diocese from 1979 to 1985.[citation needed]
On 29 May 2015, Pope Francis appointed Travas Bishop of Multan.[10] He received his episcopal consecration on 15 August 2015 from Archbishop Ghaleb Moussa Abdalla Bader, Apostolic Nuncio to Pakistan.[11]
On 11 February 2021, Pope Francis appointed Travas to succeed Joseph Coutts as Archbishop of Karachi.[12]
On 9 December 2022, Pope Francis appointed Fr. Yousaf Sohan as Bishop of Multan.[13] In a 12 December 2022 interview the Bishop-elect outlined his plans to promote education in the diocese. He plans to build more schools and enable homeless children to access education. The Catholic Board of Education, Multan, currently manages 27 schools which provide education to thousands.[14]
Marian shrine
The diocese administers the shrine of Mary, Queen of Thal, built on the pattern of the shrine of Our Lady of Lourdes in 1988.[15]