Eeles' research is focussed on the genetic causes of prostate cancer and identifying patients with increased risk of developing the disease.[7] She leads a UK clinical trial investigating the impact of regular screening for patients with increased risk of prostate cancer due to BRCA mutations.[8] Eeles also established PRACTICAL, an international consortium that allows researchers to share genetic data from prostate cancer patients. Her research group are part of the International Cancer Genome Consortium (ICGC).[9]