SORD

SORD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PL8, 1PL6, 1PL7
Identifiers
Aliases	SORD, HEL-S-95n, SORD1, sorbitol dehydrogenase, XDH, RDH, SDH, SORDD
External IDs	OMIM: 182500; MGI: 98266; HomoloGene: 56080; GeneCards: SORD; OMA:SORD - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	45,077,185 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,095,821 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; prostate; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; islet of Langerhans; ; ventricular zone;
	Top expressed in
	seminiferous tubule; ; spermatid; ; right kidney; ; spermatocyte; ; left lobe of liver; ; human kidney; ; seminal vesicula; ; morula; ; blastocyst; ; myocardium of ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	NAD binding; zinc ion binding; metal ion binding; L-iditol 2-dehydrogenase activity; oxidoreductase activity; D-xylulose reductase activity; carbohydrate binding; identical protein binding; (R,R)-butanediol dehydrogenase activity; ribitol 2-dehydrogenase activity;
Cellular component	cytosol; cell projection; membrane; mitochondrial membranes; cilium; mitochondrion; motile cilium; extracellular exosome; extracellular space;
Biological process	flagellated sperm motility; response to cadmium ion; response to copper ion; sorbitol catabolic process; fructose biosynthetic process; glucuronate catabolic process to xylulose 5-phosphate; response to osmotic stress; L-xylitol metabolic process; response to nutrient levels; glucose metabolic process; L-xylitol catabolic process; response to hormone; sorbitol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6652
	20322
	ENSG00000140263
	ENSMUSG00000027227
	Q00796
	Q64442
	NM_003104
	NM_146126
	NP_003095
	NP_666238
	Wikidata
View/Edit Human	View/Edit Mouse

Sorbitol dehydrogenase is an enzyme that in humans is encoded by the SORD gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140263 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027227 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Iwata T, Popescu NC, Zimonjic DB, Karlsson C, Hoog JO, Vaca G, Rodriguez IR, Carper D (Jul 1995). "Structural organization of the human sorbitol dehydrogenase gene (SORD)". Genomics. 26 (1): 55–62. doi:10.1016/0888-7543(95)80082-W. PMID 7782086.
^ "Entrez Gene: SORD sorbitol dehydrogenase".

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Karlsson C, Maret W, Auld DS, et al. (1990). "Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme". Eur. J. Biochem. 186 (3): 543–50. doi:10.1111/j.1432-1033.1989.tb15240.x. PMID 2691249.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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Klimacek M, Hellmer H, Nidetzky B (2007). "Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase". Biochem. J. 404 (3): 421–9. doi:10.1042/BJ20061384. PMC 1896283. PMID 17343568.