Sam Doumit starred in the film The Hot Chick with Rob Schneider, Adam Sandler, Anna Faris, and Rachel McAdams as well as the independent film The Utopian Society. She is featured in the Zed video clip "Starlight", included on The Hot Chick DVD. She guest starred on ABC's Castle, Showtime's series Shameless, Criminal Minds, The Mentalist on CBS, and Harry’s Law with Kathy Bates. Doumit guest-starred in the series finale of the series LAX. She played Allison in the never-aired series The Jake Effect with Jason Bateman. She played "Maggie", a recurring character on Disney's Honey, I Shrunk the Kids: The TV Show. Sam was a series regular on MTV's first scripted series Undressed, playing Jana. Doumit worked with her friend, actor Jeremy Sisto, in the series finale of Dawson's Creek and the film Little Savant. Doumit played a drug addled prostitute in an episode of Southland. She played the lead role “Rosie” in the 10 episode limited series Red Riding Hoods
Doumit began acting on stage at age 5. She has performed in over 30 professional plays including "Bonnie" in Hurlyburly, "Laura" in The Glass Menagerie and "Juliet" in Romeo and Juliet. She played a stage actress in KY2 in 2000.
In October 2005, she wrote, directed and performed "Not to Fear", a daring performance art piece in the Half-Hour From Home: Cal-Arts Alumni at Barnsdall, organized by Cal-Arts.
Samia Doumit played "Kate" in Shakespeare's The Taming of the Shrew at the Lillian Theatre in Los Angeles. Her portrayal of "Kate" was featured in an interview and article for Estylo Magazine. In 2009-2010 Doumit played 8 comedic characters in the long running hit Jewtopia at The Greenway Court Theatre in Los Angeles.
Doumit is the face of the SuicideGirls logo. She hosted "Suicide Girls Radio" Sunday nights on Indie 103.1 FM in Los Angeles from 2006 to 2011. It was voted #1 Radio in 2009 by Rolling Stone Magazine