After being discovered in junior high school, Epps starred in the low budget, short film Gowanus, Brooklyn alongside Matt Kerr, playing the role of "Drey", a high school student. The short film won the Short Filmmaking Award at "Sundance Film Festival" in 2004.[citation needed]
The success of Gowanus, Brooklyn led to a full-length feature film, Half Nelson. Released August 11, 2006 the story concerns an inner city middle-school teacher who forms a friendship with one of his students after she discovers that he has a drug habit. Epps reprised her role as "Drey" and the role of the teacher was replaced by Ryan Gosling. The film also starred rising star Anthony Mackie.[1]
In 2007, Epps acted in Aliens vs. Predator: Requiem as Kendra although her portrayal of Kendra was almost entirely omitted from the theatrical as well as the home video release. She has one scene left in the final cut, as an extra at the Gunnison Diner along with her onscreen brother Meshach Peters.[5][6]
In 2009, Shareeka provided spoken word vocals on the songs "Intro" and "Werewolf Heart" from Dead Man's Bones eponymous debut album. Ryan Gosling, who co-starred in Half Nelson, is one of the two members of Dead Man's Bones.