In 1593, he was elected Member of Parliament for Clitheroe, in 1601 MP for Helston and in 1606 MP for Thetford. He was created a baronet on 29 June 1611. In 1614, he was re-elected MP for Thetford and finally served as MP for Winchelsea from 1628 until his death.
Twysden was a great collector of manuscripts and knew Hebrew, Greek, and other languages.[1]
^Marie-Louise Coolahan, ‘Twysden, Anne, Lady Twysden (1574–1638)’, Oxford Dictionary of National Biography, Oxford University Press, 2004 accessed 14 Jan 2017