Theobromine poisoning, also informally called chocolate poisoning or cocoa poisoning, is an overdosage reaction to the xanthinealkaloidtheobromine, found in chocolate, tea, cola beverages,[1] and some other foods.
Sources
Cocoa powder contains about 2.1% theobromine by weight,[2] so 14 g (0.5 oz) of raw cocoa contains approximately 0.3 g theobromine.
Processed chocolate, in general, has smaller amounts. The amount found in highly refined chocolate candies or sweets (typically 1.4–2.1 g/kg or 40–60 mg/oz) is much lower than that of dark chocolate or unsweetened baking chocolate (>14 g/kg or >400 mg/oz).
In species
Humans
Pharmacology
Theobromine has a half-life of 10 hours, but over 16% may be unmodified 48 h after a single dose of 10 mg/kg (0.00016 oz/lb)[3]
In general, the amount of theobromine found in chocolate is small enough that chocolate can be safely consumed by humans with a negligible risk of poisoning.[4]
Toxicity
Theobromine doses at 0.8–1.5 g per day, such as may be found in 50–100 g (1.8–3.5 oz) of cocoa powder may be accompanied by sweating, trembling and severe headaches. These are the mild-to-moderate symptoms.[citation needed]
Limited mood effects were shown at 250 mg per day.[citation needed]
In other species
Toxicity
Median lethal (LD50) doses of theobromine have only been published for cats, dogs, rats, and mice; these differ by a factor of 6 across species.[6]
Serious poisoning happens more frequently in domestic animals, which metabolize theobromine much more slowly than humans,[7] and can easily consume enough chocolate to cause poisoning. The most common victims of theobromine poisoning are dogs,[8][9] for whom it can be fatal. The toxic dose for cats is even lower than for dogs.[10] However, cats are less prone to eating chocolate since they are unable to taste sweetness.[11] Theobromine is less toxic to rats and mice, who all have an LD50 of about 1,000 mg/kg (0.016 oz/lb).
In dogs, the biological half-life of theobromine is 17.5 hours; in severe cases, clinical symptoms of theobromine poisoning can persist for 72 hours.[12] Medical treatment performed by a veterinarian involves inducing vomiting within two hours of ingestion and administration of benzodiazepines or barbiturates for seizures, antiarrhythmics for heart arrhythmias, and fluid diuresis. Theobromine is also suspected to induce right atrial cardiomyopathy after long term exposure at levels equivalent to approximately 15 g/kg (0.24 oz/lb) of dark chocolate per day.[13] According to the Merck Veterinary Manual, baker's chocolate of approximately 1.3 g/kg (0.021 oz/lb) of a dog's body weight is sufficient to cause symptoms of toxicity.[14] For example, 0.4 oz (11 g) of baker's chocolate would be enough to produce mild symptoms in a 20 lb (9.1 kg) dog, while a 25% cacao chocolate bar (like milk chocolate) would be only 25% as toxic as the same dose of baker's chocolate.[15] One ounce of milk chocolate per pound of body weight (63 g/kg) is a potentially lethal dose in dogs.[14]
^Gennaro, M. C.; Abrigo, C. (1992). "Caffeine and theobromine in coffee, tea and cola-beverages or any other fizzy drinks". Fresenius' Journal of Analytical Chemistry. 343 (6): 523–525. doi:10.1007/BF00322162. ISSN0937-0633. S2CID102045933.
^Parasramka, S; Dufresne, A (September 2012). "Supraventricular tachycardia induced by chocolate: is chocolate too sweet for the heart?". The American Journal of Emergency Medicine. 30 (7): 1325.e5–7. doi:10.1016/j.ajem.2011.06.032. PMID21871761.
^Gwaltney-Brant, Sharon (February 2001). "Chocolate Intoxication"(PDF). Veterinary Medicine Publishing Group. Archived from the original(PDF) on February 22, 2016. Retrieved April 5, 2016.
^H. Gans, Joseph (1980). "Effects of short-term and long-term theobromine administration to male dogs". Toxicology and Applied Pharmacology. 53 (3): 481–96. doi:10.1016/0041-008X(80)90360-9. PMID6446176.