Turmerones are a group of related chemical compounds of the sesquiterpene class. They are found in turmeric (Curcuma longa ),[ 1] from which they derive their name, as well as other related plants such as Curcuma caesia .[ 2] There are multiple structural types of turmerones which differ in the number and placement of double bonds including α-tumerone, β-turmerone (also known as curlone), and ar-turmerone. Each of these types consists of multiple stereoisomers .
A number of in vitro biological activities of turmerones have been reported, including antiinflammatory , immunomodulatory , antiproliferative , and antifungal activities.[ 3] [ 4] [ 5]
Example chemical structures
α-turmerone
β-turmerone
ar-turmerone
(S)-turmerone
(S )-α-turmerone
(+)-β-turmerone
(S )-ar-turmerone
References
^ Xiang, Hongping; Zhang, Lanyue; Xi, Lu; Yang, Yan; Wang, Xiaowei; Lei, Dehua; Zheng, Xi; Liu, Xiaoxuan (2018). "Phytochemical profiles and bioactivities of essential oils extracted from seven Curcuma herbs". Industrial Crops and Products . 111 : 298–305. doi :10.1016/j.indcrop.2017.10.035 .
^ Dosoky, Noura; Setzer, William (2018). "Chemical Composition and Biological Activities of Essential Oils of Curcuma Species" . Nutrients . 10 (9): 1196. doi :10.3390/nu10091196 . PMC 6164907 . PMID 30200410 .
^ Takemoto, Yuki; Kishi, Chihiro; Ehira, Hinano; Matsui, Nobutaka; Yamaguchi, Taichi; Yoshioka, Yuri; Matsumura, Shinichi; Moriyama, Tatsuya; Zaima, Nobuhiro (2022). "Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice" . Scientific Reports . 12 (1): 11039. Bibcode :2022NatSR..1211039T . doi :10.1038/s41598-022-15168-9 . PMC 9247068 . PMID 35773461 .
^ Obulesu, Magisetty (2021). "Health benefits of turmeric: Emphasis on anticancer activity". Turmeric and Curcumin for Neurodegenerative Diseases . pp. 3–18. doi :10.1016/B978-0-12-822448-9.00006-6 . ISBN 9780128224489 . S2CID 234175081 .
^ Kuttan, Ramadasan; Liju, Vijayastelterb; Jeena, Kottarapat (2011). "An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa . L" . Indian Journal of Pharmacology . 43 (5): 526–531. doi :10.4103/0253-7613.84961 . PMC 3195121 . PMID 22021994 .