Vesicle-fusing ATPase

Vesicle-fusing ATPase
NSF (= N-ethylmaleimide sensitive factor) hexamer, Hamster
Identifiers
EC no.	3.6.4.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a vesicle-fusing ATPase (EC 3.6.4.6) is an enzyme that catalyzes the chemical reaction

ATP + H₂O ${\displaystyle \rightleftharpoons }$ ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (vesicle-fusing).

• Confalonieri F, Duguet M (1995). "A 200-amino acid ATPase module in search of a basic function". BioEssays. 17 (7): 639–50. doi:10.1002/bies.950170710. PMID 7646486.
• Orii T, Kondo N, Osumi T, Fujiki Y (1998). "Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders". Hum. Mol. Genet. 7 (13): 2089–94. doi:10.1093/hmg/7.13.2089. PMID 9817926.
• Babst M, Wendland B, Estepa EJ, Emr SD (1998). "The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function". EMBO J. 17 (11): 2982–93. doi:10.1093/emboj/17.11.2982. PMC 1170638. PMID 9606181.