Zosurabalpin (RG6006, Abx-MCP, Ro7223280) is an experimental antibiotic developed in a collaboration between the pharmaceutical company Roche and scientists from Harvard University, for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB). It targets a lipopolysaccharide transporter.[1] It works by recognizing a composite binding site made up of both the Lpt transporter and its LPS substrate.[2] The chemical family to which it belongs was first disclosed in 2019, but the particular structure of RG6006 remained confidential until publication of the testing results in 2023.[3][4][5]
^US 20190321440A1, Bleicher K, Cheang D, Di Giorgio P, Hu T, Jenny C, Mattei P, Schmitz P, Stoll T, "Peptide macrocycles against acinetobacter baumannii.", issued 21 November 2023, assigned to Hoffmann La Roche Inc.
^Erbetti I, Ferrari L, Ortombina A, Savoia P, Felici A, Bissantz C, Zampaloni C (December 2023). "2109. In vitro and in vivo Killing Kinetics of Zosurabalpin (RG6006) Against Acinetobacter baumannii.". Open Forum Infectious Diseases. Vol. 10. Oxford University Press. doi:10.1093/ofid/ofad500.1733.