CLEC4A
عضو A از خانوادهٔ ۴ دومِـین لکتین نوع سی (انگلیسی: C-type lectin domain family 4 member A) یک پروتئین است که در انسان توسط ژن «CLEC4A» کُدگذاری میشود.[۵][۶]
پروتئین حاصله یکی از اعضای خانوادهٔ بزرگ پروتئینهای حاوی لکتین نوع سی است که همگی در چسبندگی سلولی، پیامرسانی سلول-به-سلول، تجدید و بازیافت گلیکوپروتئین، التهاب و پاسخ ایمنی نقش دارند.
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000111729 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030148 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol. 163 (4): 1973–83. PMID 10438934.
- ↑ "Entrez Gene: CLEC4A C-type lectin domain family 4, member A".
- مشارکتکنندگان ویکیپدیا. «CLEC4A». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۴ دسامبر ۲۰۱۹.
برای مطالعهٔ بیشتر
- Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
- Huang X, Yuan Z, Chen G, et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants". Biochem. Biophys. Res. Commun. 281 (1): 131–40. doi:10.1006/bbrc.2001.4322. PMID 11178971.
- Richard M, Veilleux P, Rouleau M, et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation". J. Leukoc. Biol. 71 (5): 871–80. PMID 11994513.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
- Richard M, Thibault N, Veilleux P, et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents". Biochem. Biophys. Res. Commun. 310 (3): 767–73. doi:10.1016/j.bbrc.2003.09.077. PMID 14550269.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Richard M, Thibault N, Veilleux P, et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2". Mol. Immunol. 43 (10): 1716–21. doi:10.1016/j.molimm.2005.10.006. PMID 16360206.
- Lorentzen JC, Flornes L, Eklöw C, et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors". Arthritis Rheum. 56 (8): 2620–32. doi:10.1002/art.22813. PMID 17665455.
پیوند به بیرون
- مکان ژنوم CLEC4A انسانی و صفحهٔ جزئیات ژنی CLEC4A در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
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