MLST8
مولکول هدفِ کمپلکس راپامایسین، زیرواحد الاستی۸ (انگلیسی: Target of rapamycin complex subunit LST8) مشهور به «پروتئین ۸ کشنده با اسئیسی۱۳ پستانداران» یک پروتئین است که در انسان توسط ژن «MLST8» کُدگذاری میشود.[۵] این مولکول زیرواحد هر دو کمپلکس پروتئینی «mTORC1» و «mTORC2» است که در تنظیم رشد و بقای سلول در پاسخ به مواد مغذی، انرژی، اکسایش-کاهش و پیامهای هورمونی نقش دارند.[۶] تخریب ژن «MLST8» از تشکیل کمپلکس پروتئینی mTORC جلوگیری کرده و جلوی رشد سرطانی سلولها و حالت تهاجمی تومور را میگیرد.[۷]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000167965 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024142 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: MTOR associated protein".
- ↑ "UniProtKB – Q9BVC4 (LST8_HUMAN)".
- ↑ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 Apr 2015). "mLST8 Promotes mTOR-Mediated Tumor Progression". PLOS ONE. 10 (4): e0119015. Bibcode:2015PLoSO..1019015K. doi:10.1371/journal.pone.0119015. PMC 4408021. PMID 25906254.
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- مشارکتکنندگان ویکیپدیا. «MLST8». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۲ سپتامبر ۲۰۲۲.
برای مطالعهٔ بیشتر
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