SPINK1
بازدارندهٔ تریپسین ترشحی لوزالمعده (انگلیسی: Pancreatic secretory trypsin inhibitor) با نام اختصاری «PSTI» که با نام بازدارندهٔ سرین پروتئاز شبه کازال ۱ (SPINK1) و بازدارندهٔ تریپسین مرتبط با تومور (TATI) هم شناخته میشود، یک پروتئین است که در انسان توسط ژن «SPINK1» بر روی بازوی بلند کروموزوم ۵ کُدگذاری میشود.[۵]
اهمیت بالینی
جهش در این ژن موجب بروز پانکراتیت ارثی و پانکراتیت استوایی میشود. در واقع اگر این پروتئین کارش را بهدرستی انجام ندهد، لوزالمعده در معرض آسیبهای مکرر بافتی است.[۶] این پروتئین همچنین با بروز سرطان پروستات در ارتباط است.[۷]
جستارهای وابسته
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000164266 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024503 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: SPINK1 serine peptidase inhibitor, Kazal type 1".
- ↑ Schneider, A. "SPINK1 - serine peptidase inhibitor, Kazal type 1". Wikigenes.
- ↑ Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, et al. (Jun 2008). "The role of SPINK1 in ETS rearrangement-negative prostate cancers". Cancer Cell. 13 (6): 519–28. doi:10.1016/j.ccr.2008.04.016. PMC 2732022. PMID 18538735.
برای مطالعهٔ بیشتر
- Marchbank T, Freeman TC, Playford RJ (1998). "Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair". Digestion. 59 (3): 167–74. doi:10.1159/000007485. PMID 9643675.
- Pfützer RH, Whitcomb DC (2002). "SPINK1 mutations are associated with multiple phenotypes". Pancreatology. 1 (5): 457–60. doi:10.1159/000055847. PMID 12120224. S2CID 8123648.
- Schneider A (Mar 2005). "Serine protease inhibitor kazal type 1 mutations and pancreatitis". Clinics in Laboratory Medicine. 25 (1): 61–78. doi:10.1016/j.cll.2004.12.005. PMID 15749232.
- Cohn JA, Mitchell RM, Jowell PS (Mar 2005). "The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis". Clinics in Laboratory Medicine. 25 (1): 79–100. doi:10.1016/j.cll.2004.12.007. PMID 15749233.
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- Bartelt DC, Shapanka R, Greene LJ (Feb 1977). "The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein". Archives of Biochemistry and Biophysics. 179 (1): 189–99. doi:10.1016/0003-9861(77)90103-5. PMID 843082.
- Hecht HJ, Szardenings M, Collins J, Schomburg D (Jun 1992). "Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type)". Journal of Molecular Biology. 225 (4): 1095–103. doi:10.1016/0022-2836(92)90107-U. PMID 1613792.
- Hecht HJ, Szardenings M, Collins J, Schomburg D (Aug 1991). "Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type)". Journal of Molecular Biology. 220 (3): 711–22. doi:10.1016/0022-2836(91)90112-J. PMID 1870127.
- Freeman TC, Davies R, Calam J (Dec 1990). "Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors". Clinica Chimica Acta; International Journal of Clinical Chemistry. 195 (1–2): 27–39. doi:10.1016/0009-8981(90)90191-T. PMID 2093478.
- Kido H, Yokogoshi Y, Katunuma N (Mar 1990). "A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence". European Journal of Biochemistry. 188 (3): 501–6. doi:10.1111/j.1432-1033.1990.tb15428.x. PMID 2110056.
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- Horii A, Kobayashi T, Tomita N, Yamamoto T, Fukushige S, Murotsu T, Ogawa M, Mori T, Matsubara K (Dec 1987). "Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene". Biochemical and Biophysical Research Communications. 149 (2): 635–41. doi:10.1016/0006-291X(87)90415-3. PMID 3501289.
- Yamamoto T, Nakamura Y, Nishide J, Emi M, Ogawa M, Mori T, Matsubara K (Oct 1985). "Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA". Biochemical and Biophysical Research Communications. 132 (2): 605–12. doi:10.1016/0006-291X(85)91176-3. PMID 3877508.
- Huhtala ML, Pesonen K, Kalkkinen N, Stenman UH (Nov 1982). "Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer". The Journal of Biological Chemistry. 257 (22): 13713–6. doi:10.1016/S0021-9258(18)33505-1. PMID 7142173.
- Klaus W, Schomburg D (Feb 1993). "Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy". Journal of Molecular Biology. 229 (3): 695–706. doi:10.1006/jmbi.1993.1073. PMID 8433367.
- Chen JM, Mercier B, Audrezet MP, Ferec C (Jan 2000). "Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis". Journal of Medical Genetics. 37 (1): 67–9. doi:10.1136/jmg.37.1.67. PMC 1734438. PMID 10691414.
- Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M (Jun 2000). "Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis". Nature Genetics. 25 (2): 213–6. doi:10.1038/76088. PMID 10835640. S2CID 23661289.
- Pfützer RH, Barmada MM, Brunskill AP, Finch R, Hart PS, Neoptolemos J, Furey WF, Whitcomb DC (Sep 2000). "SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis". Gastroenterology. 119 (3): 615–23. doi:10.1053/gast.2000.18017. PMID 10982753.
- Kaneko K, Nagasaki Y, Furukawa T, Mizutamari H, Sato A, Masamune A, Shimosegawa T, Horii A (2001). "Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis". Journal of Human Genetics. 46 (5): 293–7. doi:10.1007/s100380170082. PMID 11355022.
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