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TFG
معین‌کننده‌ها
نام‌های دیگر	TFG, HMSNP, SPG57, TF6, TRKT3, TRK-fused gene, trafficking from ER to golgi regulator
شناسه‌های بیرونی	OMIM: 602498; MGI: 1338041; HomoloGene: 4426; GeneCards: TFG; OMA:TFG - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۳ (انسان)
پایان	100,748,964 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۶ (موش)
پایان	56,537,813 bp
الگوی گسترش RNA
	بیشترین بیان در
	secondary oocyte; ; jejunal mucosa; ; gingival epithelium; ; parietal pleura; ; stromal cell of endometrium; ; oral cavity;
	بیشترین بیان در
	gastrula; ; epithelium of small intestine; ; tail of embryo;
	داده‌های بیشتر بیان
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	پیوند پروتئینی; signal transducer activity; identical protein binding;
ترکیبات سلولی	سیتوپلاسم; سیتوزول; اگزوزوم; Golgi membrane; endoplasmic reticulum exit site; شبکه آندوپلاسمی;
فرایند زیستی	positive regulation of I-kappaB kinase/NF-kappaB signaling; ورارسانی پیام; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10342
	21787
	ENSG00000114354
	ENSMUSG00000022757
	Q92734
	ناموجود
	NM_001007565; NM_001195478; NM_001195479; NM_006070
	NM_001252443; NM_019678; NM_001357124; NM_001357125; NM_001357126
	NP_001007566; NP_001182407; NP_001182408; NP_006061
	ناموجود
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین TFG (انگلیسی: Protein TFG) یک پروتئین است که در انسان توسط ژن «TFG» کدگذاری می‌شود.^[۵]^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000114354 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022757 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P (May 1997). "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma". Genomics. 41 (3): 327–31. doi:10.1006/geno.1997.4625. PMID 9169129.
↑ "Entrez Gene: TFG TRK-fused gene".

مشارکت‌کنندگان ویکی‌پدیا. «TFG (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۷ اکتبر ۲۰۱۸.

بیشتر بخوانید

Sasaoka T, Kobayashi M (Aug 2000). "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor". Endocrine Journal. 47 (4): 373–81. doi:10.1507/endocrj.47.373. PMID 11075717.
Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA (Nov 1995). "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain". Molecular and Cellular Biology. 15 (11): 6118–27. doi:10.1128/mcb.15.11.6118. PMC 230863. PMID 7565764.
Gotoh N, Toyoda M, Shibuya M (Apr 1997). "Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation". Molecular and Cellular Biology. 17 (4): 1824–31. doi:10.1128/mcb.17.4.1824. PMC 232029. PMID 9121430.
Soltoff SP, Avraham H, Avraham S, Cantley LC (Jan 1998). "Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C". The Journal of Biological Chemistry. 273 (5): 2653–60. doi:10.1074/jbc.273.5.2653. PMID 9446569.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Walk SF, March ME, Ravichandran KS (Aug 1998). "Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc". European Journal of Immunology. 28 (8): 2265–75. doi:10.1002/(SICI)1521-4141(199808)28:08<2265::AID-IMMU2265>3.0.CO;2-P. PMID 9710204.
Wary KK, Mariotti A, Zurzolo C, Giancotti FG (Sep 1998). "A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth". Cell. 94 (5): 625–34. doi:10.1016/S0092-8674(00)81604-9. PMID 9741627.
Marchetto S, Fournier E, Beslu N, Aurran-Schleinitz T, Dubreuil P, Borg JP, Birnbaum D, Rosnet O (Sep 1999). "SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor". Leukemia. 13 (9): 1374–82. doi:10.1038/sj/leu/2401527. PMID 10482988.
Hernández L, Pinyol M, Hernández S, Beà S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E (Nov 1999). "TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations". Blood. 94 (9): 3265–8. PMID 10556217.
Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K (Jul 2000). "Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells". The Journal of Biological Chemistry. 275 (27): 20880–6. doi:10.1074/jbc.M905410199. PMID 10764799.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Slack BE (Jun 2000). "The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase". The Biochemical Journal. 348 (2): 381–7. doi:10.1042/0264-6021:3480381. PMC 1221077. PMID 10816433.
Schaak S, Cussac D, Cayla C, Devedjian JC, Guyot R, Paris H, Denis C (Aug 2000). "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells". Gut. 47 (2): 242–50. doi:10.1136/gut.47.2.242. PMC 1728001. PMID 10896916.
Imokawa G, Kobayasi T, Miyagishi M (Oct 2000). "Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor". The Journal of Biological Chemistry. 275 (43): 33321–8. doi:10.1074/jbc.M004346200. PMID 10921922.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Hernández L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fernández A, Pulford K, Mason D, Morris SW, Santos E, Campo E (Apr 2002). "Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity". The American Journal of Pathology. 160 (4): 1487–94. doi:10.1016/S0002-9440(10)62574-6. PMC 1867210. PMID 11943732.
Roccato E, Miranda C, Ranzi V, Gishizki M, Pierotti MA, Greco A (Sep 2002). "Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc". British Journal of Cancer. 87 (6): 645–53. doi:10.1038/sj.bjc.6600544. PMC 2364237. PMID 12237775.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.

پیوند به بیرون

مکان ژن انسانی TFG در مرورگر ژنومی UCSC.
جزئیات ژن انسانی TFG در مرورگر ژنومی UCSC.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000114354 – Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022757 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169129-5] Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P (May 1997). "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma". Genomics. 41 (3): 327–31. doi:10.1006/geno.1997.4625. PMID 9169129.

[entrez-6] "Entrez Gene: TFG TRK-fused gene".

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TFG

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