3F8

3F8
Monoklonalno antitelo
Tip?
IzvorМиш
MetaGD2
Klinički podaci
Način primeneintravenozno
Identifikatori
ATC kodnone
ChemSpiderNA Зелена квачицаДа

3F8 je glodarsko IgG3[1] monoklonalno antitelo koje se vezuje za GD2.[2]

3F8 antitelo je korišteno za detekciju i tretman neuroblastoma. Kad se koristi za snimanje neuroblastoma, ono je obeleženo sa jednim od radioizotopa jod-124 ili jod-131.[3][4]

Reference

  1. ^ Kushner BH, Cheung NK (1989). „GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma”. Blood. 73 (7): 1936—41. PMID 2653466. Архивирано из оригинала 26. 05. 2020. г. Приступљено 24. 10. 2012. 
  2. ^ „Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A”. Приступљено 19. 2. 2008. 
  3. ^ Yeh SD; Larson SM; Burch L; et al. (1991). „Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities”. J. Nucl. Med.. 32 (5): 769—76. PMID 1902508. 
  4. ^ Dauer LT; St Germain J; Williamson MJ; et al. (2007). „Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma”. Health Phys. 92 (1): 33—9. PMID 17164597. doi:10.1097/01.HP.0000231583.32904.6c. 

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