Alvimopan

Alvimopan
Klinički podaci
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj170098-38-1 Зелена квачицаДа
ATC kodA06AH02 (WHO)
PubChemCID 5488548
DrugBankDB06274 Зелена квачицаДа
ChemSpider4589864 Зелена квачицаДа
ChEMBLCHEMBL270190 Зелена квачицаДа

Alvimopan je organsko jedinjenje, koje sadrži 25 atoma ugljenika i ima molekulsku masu od 424,533 Da.[1][2][3][4]

Osobine

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 3
Broj rotacionih veza 8
Particioni koeficijent[5] (ALogP) 0,5
Rastvorljivost[6] (logS, log(mol/L)) -5,8
Polarna površina[7] (PSA, Å2) 89,9

Reference

  1. ^ Buchler MW, Seiler CM, Monson JR, Flamant Y, Thompson-Fawcett MW, Byrne MM, Mortensen ER, Altman JF, Williamson R: Clinical trial: alvimopan for the management of postoperative ileus after abdominal surgery: results of an international randomised, double-blind, multicentre, placebo-controlled clinical study. 2008 Mar 28. Aliment Pharmacol Ther. PMID 18373729.  Недостаје или је празан параметар |title= (помоћ)
  2. ^ Wang S, Shah N, Philip J, Caraccio T, Feuerman M, Malone B. „Role of alvimopan (entereg) in gastrointestinal recovery and hospital length of stay after bowel resection”. P T. 37 (9): 518—25. 2012 Sep. PMID 23066346.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  3. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  4. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  5. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  6. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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