Busulfan

Busulfan
Klinički podaci
Prodajno imeBusulfex, Citosulfan, Leucosulfan, Mablin
Drugs.comMonografija
Način primeneIntravenozno, oralno
Identifikatori
CAS broj55-98-1 Зелена квачицаДа
ATC kodL01AB01 (WHO)
PubChemCID 2478
DrugBankDB01008 Зелена квачицаДа
ChemSpider2384 Зелена квачицаДа
ChEBICHEBI:28901 Зелена квачицаДа
ChEMBLCHEMBL820 Зелена квачицаДа

Busulfan je organsko jedinjenje, koje sadrži 6 atoma ugljenika i ima molekulsku masu od 246,302 Da.[1][2][3][4][5][6][7][8][9]

Osobine

Osobina Vrednost
Broj akceptora vodonika 6
Broj donora vodonika 0
Broj rotacionih veza 7
Particioni koeficijent[10] (ALogP) -0,3
Rastvorljivost[11] (logS, log(mol/L)) -1,3
Polarna površina[12] (PSA, Å2) 103,5

Reference

  1. ^ Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA. „Platelet-derived serotonin mediates liver regeneration”. Science. 312 (5770): 104—7. 2006 Apr 7. PMID 16601191.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  2. ^ Valdez BC, Andersson BS. „Interstrand crosslink inducing agents in pretransplant conditioning therapy for hematologic malignancies”. Environ Mol Mutagen. 51 (6): 659—68. 2010 Jul. PMID 20577993.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  3. ^ Hall AG, Tilby MJ. „Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies”. Blood Rev. 6 (3): 163—73. 1992 Sep. PMID 1422285.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  4. ^ Ciurea SO, Andersson BS. „Busulfan in hematopoietic stem cell transplantation”. Biol Blood Marrow Transplant. 15 (5): 523—36. 2009 May. PMID 19361744.  Проверите вредност парамет(а)ра за датум: |date= (помоћ) Feb 12.
  5. ^ McCune JS, Holmberg LA. „Busulfan in hematopoietic stem cell transplant setting”. Expert Opin Drug Metab Toxicol. 5 (8): 957—69. 2009 Aug. PMID 19611402.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  6. ^ Krivoy N, Hoffer E, Lurie Y, Bentur Y, Rowe JM. „Busulfan use in hematopoietic stem cell transplantation: pharmacology, dose adjustment, safety and efficacy in adults and children”. Curr Drug Saf. 3 (1): 60—6. 2008 Jan. PMID 18690982.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  7. ^ Nath CE, Shaw PJ. „Busulphan in blood and marrow transplantation: dose, route, frequency and role of therapeutic drug monitoring”. Curr Clin Pharmacol. 2 (1): 75—91. 2007 Jan. PMID 18690856.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  8. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  9. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  10. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  11. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  12. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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